| Gene Symbol |
ANKRD27
|
| Entrez Gene |
84079
|
| Alt Symbol |
PP12899, VARP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ankyrin repeat domain 27 (VPS9 domain)
|
| Other Description |
VPS9 domain-containing protein|VPS9-ankyrin-repeat protein|Vps9 domain and ankyrin-repeat-containing protein|ankyrin repeat domain-containing protein 27
|
| Swissprots |
Q96NW4 Q9H0I4 Q86UC3 Q8ND80 Q71MF5
|
| Accessions |
Q96NW4 AA903176 AF447882 AAQ04657 AK054561 BAB70755 AL136784 CAB66718 AL834335 CAD39003 AM393863 CAL38738 BC015552 BC045605 BC050529 AAH50529 BI462844 XM_005259310 XP_005259367 XM_006723412 XP_006723475 NM_032139 NP_115515
|
| Function |
May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites
|
| Subcellular Location |
Early endosome {ECO:0000269|PubMed:16525121, ECO:0000269|PubMed:24856514}. Late endosome {ECO:0000269|PubMed:23104059}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:23104059}. Lysosome {ECO:0000269|PubMed:23104059}. Cell membrane {ECO:0000269|PubMed:23104059}. Melanosome {ECO:0000250|UniProtKB:Q3UMR0}. Note=Colocalizes with VAMP7 in transport vesicles in the shaft of hippoocampal neurons (By similarity). {ECO:0000250|UniProtKB:Q3UMR0}.
|