ANKRD27

Gene Symbol	ANKRD27
Entrez Gene	84079
Alt Symbol	PP12899, VARP
Species	Human
Gene Type	protein-coding
Description	ankyrin repeat domain 27 (VPS9 domain)
Other Description	VPS9 domain-containing protein|VPS9-ankyrin-repeat protein|Vps9 domain and ankyrin-repeat-containing protein|ankyrin repeat domain-containing protein 27
Swissprots	Q96NW4 Q9H0I4 Q86UC3 Q8ND80 Q71MF5
Accessions	Q96NW4 AA903176 AF447882 AAQ04657 AK054561 BAB70755 AL136784 CAB66718 AL834335 CAD39003 AM393863 CAL38738 BC015552 BC045605 BC050529 AAH50529 BI462844 XM_005259310 XP_005259367 XM_006723412 XP_006723475 NM_032139 NP_115515
Function	May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites
Subcellular Location	Early endosome {ECO:0000269|PubMed:16525121, ECO:0000269|PubMed:24856514}. Late endosome {ECO:0000269|PubMed:23104059}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:23104059}. Lysosome {ECO:0000269|PubMed:23104059}. Cell membrane {ECO:0000269|PubMed:23104059}. Melanosome {ECO:0000250|UniProtKB:Q3UMR0}. Note=Colocalizes with VAMP7 in transport vesicles in the shaft of hippoocampal neurons (By similarity). {ECO:0000250|UniProtKB:Q3UMR0}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VARP full length protein - ab164491 from Abcam Category Protein Source Wheat germ Species Human

ANKRD27 Antibody Blocking Peptide - LS-E30798 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ANKRD27 Antibody Blocking Peptide - LS-E22106 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ANKRD27 Antibody Blocking Peptide - LS-E31226 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ANKRD27 Recombinant Protein - H00084079-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ANKRD27-Antibody-C-term-Blocking-peptide - BP5654b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ANKRD27 Blocking Peptide - 33R-2166 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ANKRD27 - H00084079-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ANKRD27 - H00084079-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ANKRD27 (Center) Control Peptide - AP55658CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

ANKRD27 (N-term) Control Peptide - AP55668CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

VARP Peptide - 6673P from ProSci Category Peptide Species Human

VARP Peptide - 5451P from ProSci Category Peptide Species Human

Recombinant Human Ankyrin repeat domain-containing protein 27(ANKRD27) ,partial - CSB-YP842728HU CSB-EP842728HU CSB-BP842728HU CSB-MP842728HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Ankyrin repeat domain-containing protein 27(ANKRD27) ,partial, Recombinant Protein - MBS1337504 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ANKRD27 fusion protein - ag21239 from Proteintech Group Category Protein Species Human

ANKRD27 Recombinant Protein Antigen - NBP1-85111PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ANKRD27 Peptide, Human - M34GP00633H from Creative Peptides Category Peptide Source Synthetic. Species Human

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