| Gene Symbol |
METTL14
|
| Entrez Gene |
57721
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
methyltransferase like 14
|
| Other Description |
N6-adenosine-methyltransferase subunit METTL14|methyltransferase-like protein 14
|
| Swissprots |
Q969V2 A6NIG1 Q9HCE5
|
| Accessions |
EAW73651 EAW73652 Q9HCE5 AB046847 BAB13453 AK055555 BAB70954 AK296056 BAG58819 AW206149 BC006565 AAH06565 BC007449 AAH07449 BG773151 HQ448248 ADQ32728 XM_005263166 XP_005263223 XM_011532162 XP_011530464 XR_938769 NM_020961 NP_066012
|
| Function |
N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs, thereby promoting self-renewal of ESCs. {ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421}.
|
![Western Blot: METTL14 Overexpression Lysate (Adult Normal) [NBL1-12275] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for METTL14.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3623_METTL14%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12275-img0002.jpg)