Gene Symbol | METTL14 |
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Entrez Gene | 57721 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | methyltransferase like 14 |
Other Description | N6-adenosine-methyltransferase subunit METTL14|methyltransferase-like protein 14 |
Swissprots | Q969V2 A6NIG1 Q9HCE5 |
Accessions | EAW73651 EAW73652 Q9HCE5 AB046847 BAB13453 AK055555 BAB70954 AK296056 BAG58819 AW206149 BC006565 AAH06565 BC007449 AAH07449 BG773151 HQ448248 ADQ32728 XM_005263166 XP_005263223 XM_011532162 XP_011530464 XR_938769 NM_020961 NP_066012 |
Function | N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs, thereby promoting self-renewal of ESCs. {ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:24407421}. |
METTL14 CRISPR/Cas9 KO Plasmid (h) - sc-406936 from Santa Cruz Biotechnology
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METTL14 HDR Plasmid (h) - sc-406936-HDR from Santa Cruz Biotechnology
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METTL14 Double Nickase Plasmid (h) - sc-406936-NIC from Santa Cruz Biotechnology
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METTL14 Double Nickase Plasmid (h2) - sc-406936-NIC-2 from Santa Cruz Biotechnology
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METTL14 CRISPR Activation Plasmid (h) - sc-406936-ACT from Santa Cruz Biotechnology
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METTL14 CRISPR Activation Plasmid (h2) - sc-406936-ACT-2 from Santa Cruz Biotechnology
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METTL14 Lentiviral Activation Particles (h) - sc-406936-LAC from Santa Cruz Biotechnology
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METTL14 Lentiviral Activation Particles (h2) - sc-406936-LAC-2 from Santa Cruz Biotechnology
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METTL14 siRNA (h) - sc-89054 from Santa Cruz Biotechnology
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METTL14 shRNA Plasmid (h) - sc-89054-SH from Santa Cruz Biotechnology
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METTL14 shRNA (h) Lentiviral Particles - sc-89054-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU038041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13230 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13230 from Sigma-Aldrich
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METTL14 siRNA (Human) - CRJ1661 from Cohesion Biosciences
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shRNA set against Human METTL14 (NM_020961.2) - SHH340687 from Creative biogene
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Human METTL14 siRNA - orb272162 from Biorbyt
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METTL14 shRNA Plasmid (Human) - CHJ1661 from Cohesion Biosciences
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METTL14 miRNA 3'UTR clone - MiUTR1H-05276 from Creative biogene
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