Gene Symbol |
UBXN6
|
Entrez Gene |
80700
|
Alt Symbol |
UBXD1, UBXDC2
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
UBX domain protein 6
|
Other Description |
UBX domain containing 1|UBX domain-containing 1|UBX domain-containing 2|UBX domain-containing protein 1|UBX domain-containing protein 6
|
Swissprots |
Q9BZV1 Q96AH1 Q96IK9 D6W626 Q9BZV0
|
Accessions |
EAW69219 EAW69220 EAW69221 EAW69222 EAW69223 Q9BZV1 AF272893 AAK13257 AF272894 AAK13258 AK090473 BAC03454 AL833695 BC007414 AAH07414 BC008288 AAH08288 BC017113 AAH17113 BM764980 XR_936205 NM_001171091 NP_001164562 NM_025241 NP_079517
|
Function |
Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation. {ECO:0000269|PubMed:18768758}.
|
Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18656546}. Nucleus {ECO:0000269|PubMed:18656546}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18656546}. Note=Localizes at the centrosome both in interphase and during mitosis.
|
Tissue Specificity |
Enhanced expression in testis.
|
Top Pathways |
Protein processing in endoplasmic reticulum
|