Gene Symbol | UBXN6 |
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Entrez Gene | 80700 |
Alt Symbol | UBXD1, UBXDC2 |
Species | Human |
Gene Type | protein-coding |
Description | UBX domain protein 6 |
Other Description | UBX domain containing 1|UBX domain-containing 1|UBX domain-containing 2|UBX domain-containing protein 1|UBX domain-containing protein 6 |
Swissprots | Q9BZV1 Q96AH1 Q96IK9 D6W626 Q9BZV0 |
Accessions | EAW69219 EAW69220 EAW69221 EAW69222 EAW69223 Q9BZV1 AF272893 AAK13257 AF272894 AAK13258 AK090473 BAC03454 AL833695 BC007414 AAH07414 BC008288 AAH08288 BC017113 AAH17113 BM764980 XR_936205 NM_001171091 NP_001164562 NM_025241 NP_079517 |
Function | Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation. {ECO:0000269|PubMed:18768758}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18656546}. Nucleus {ECO:0000269|PubMed:18656546}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18656546}. Note=Localizes at the centrosome both in interphase and during mitosis. |
Tissue Specificity | Enhanced expression in testis. |
Top Pathways | Protein processing in endoplasmic reticulum |
UBXD1 CRISPR/Cas9 KO Plasmid (h) - sc-410159 from Santa Cruz Biotechnology
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UBXD1 HDR Plasmid (h) - sc-410159-HDR from Santa Cruz Biotechnology
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UBXD1 Double Nickase Plasmid (h) - sc-410159-NIC from Santa Cruz Biotechnology
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UBXD1 Double Nickase Plasmid (h2) - sc-410159-NIC-2 from Santa Cruz Biotechnology
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UBXD1 CRISPR Activation Plasmid (h) - sc-410159-ACT from Santa Cruz Biotechnology
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UBXD1 CRISPR Activation Plasmid (h2) - sc-410159-ACT-2 from Santa Cruz Biotechnology
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UBXD1 Lentiviral Activation Particles (h) - sc-410159-LAC from Santa Cruz Biotechnology
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UBXD1 Lentiviral Activation Particles (h2) - sc-410159-LAC-2 from Santa Cruz Biotechnology
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UBXD1 siRNA (h) - sc-97428 from Santa Cruz Biotechnology
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UBXD1 shRNA Plasmid (h) - sc-97428-SH from Santa Cruz Biotechnology
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UBXD1 shRNA (h) Lentiviral Particles - sc-97428-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU123641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22430 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22430 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00833 from Sigma-Aldrich
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UBXN6 siRNA (Human) - CRJ2879 from Cohesion Biosciences
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UBXN6 - MBS8220963 from MyBioSource
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shRNA set against Human UBXN6 (NM_025241.2) - SHH439712 from Creative biogene
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Human UBXN6 siRNA - orb273380 from Biorbyt
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UBXN6 shRNA Plasmid (Human) - CHJ2879 from Cohesion Biosciences
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UBXN6 miRNA 3'UTR clone - MiUTR3H-12215 from Creative biogene
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