Gene Symbol | UBXN6 |
---|---|
Entrez Gene | 80700 |
Alt Symbol | UBXD1, UBXDC2 |
Species | Human |
Gene Type | protein-coding |
Description | UBX domain protein 6 |
Other Description | UBX domain containing 1|UBX domain-containing 1|UBX domain-containing 2|UBX domain-containing protein 1|UBX domain-containing protein 6 |
Swissprots | Q9BZV1 Q96AH1 Q96IK9 D6W626 Q9BZV0 |
Accessions | EAW69219 EAW69220 EAW69221 EAW69222 EAW69223 Q9BZV1 AF272893 AAK13257 AF272894 AAK13258 AK090473 BAC03454 AL833695 BC007414 AAH07414 BC008288 AAH08288 BC017113 AAH17113 BM764980 XR_936205 NM_001171091 NP_001164562 NM_025241 NP_079517 |
Function | Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation. {ECO:0000269|PubMed:18768758}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:18656546}. Nucleus {ECO:0000269|PubMed:18656546}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18656546}. Note=Localizes at the centrosome both in interphase and during mitosis. |
Tissue Specificity | Enhanced expression in testis. |
Top Pathways | Protein processing in endoplasmic reticulum |