SMEK1

Gene Symbol	SMEK1
Entrez Gene	55671
Alt Symbol	FLFL1, KIAA2010, MSTP033, PP4R3A, smk-1, smk1
Species	Human
Gene Type	protein-coding
Description	SMEK homolog 1, suppressor of mek1 (Dictyostelium)
Other Description	serine/threonine-protein phosphatase 4 regulatory subunit 3A
Swissprots	Q86YI7 Q6IN85 Q9NV01 Q9H7U8 Q9H3F1 Q86U23 Q9NWP1 Q69YK6 Q8IVG1
Accessions	EAW81452 EAW81453 EAW81454 EAW81455 EAW81456 EAW81457 Q6IN85 AB095930 BAC23106 AF113213 AAG39284 AI608781 AK000714 BAA91338 AK001885 BAA91960 AK024297 BAB14877 AL832921 CAH10634 BC018617 BC022778 BC028088 AAH28088 BC038932 AAH38932 BC072409 AAH72409 BM147425 BX248247 CAD62575 XM_005267842 XP_005267899 XM_006720194 XP_006720257 XM_011536936 XP_011535238 XR_245703 XR_943491 NM_017936 NM_032560 NM_001284280 NP_001271209 NM_001284281 NP_001271210
Function	Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:18487071}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18487071}. Nucleus {ECO:0000269|PubMed:18487071}. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.
Top Pathways	Glucagon signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMEK1 - MBS1270181 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC038932

SMEK1 - MBS1266121 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC028088

Human SMEK1 ORF Clone(NM_032560.4) - CDCL176391 from Creative Biomart Species Human Accession NM_032560.4

human SMEK1 ORF clone - CDCH083582 from Creative Biomart Species Human Accession NM_032560

human SMEK1 ORF clone - CDCH083583 from Creative Biomart Species Human Accession NM_032560

human SMEK1 ORF clone - CDCH083584 from Creative Biomart Species Human Accession NM_032560

human SMEK1 ORF clone - CDCH083585 from Creative Biomart Species Human Accession NM_032560

human SMEK1 ORF clone - CDCH083586 from Creative Biomart Species Human Accession NM_032560

human SMEK1 ORF clone - CDCH083587 from Creative Biomart Species Human Accession NM_032560

human SMEK1 ORF clone - CDCH083588 from Creative Biomart Species Human Accession NM_032560

human SMEK1 ORF clone - CDCH083589 from Creative Biomart Species Human Accession NM_032560

Human SMEK1 Gene ORF cDNA clone in cloning vector - HG15037-G from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15037-ANG from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15037-ACG from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15037-NF from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15037-NY from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, N-His tag - HG15037-NH from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15037-CF from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15037-NM from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15037-CM from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, C-His tag - HG15037-CH from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid - HG15037-UT from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15037-ACR from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15037-ANR from Sino Biological Species Human

Human SMEK1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15037-CY from Sino Biological Species Human

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