SMEK1

Gene Symbol SMEK1
Entrez Gene 55671
Alt Symbol FLFL1, KIAA2010, MSTP033, PP4R3A, smk-1, smk1
Species Human
Gene Type protein-coding
Description SMEK homolog 1, suppressor of mek1 (Dictyostelium)
Other Description serine/threonine-protein phosphatase 4 regulatory subunit 3A
Swissprots Q86YI7 Q6IN85 Q9NV01 Q9H7U8 Q9H3F1 Q86U23 Q9NWP1 Q69YK6 Q8IVG1
Accessions EAW81452 EAW81453 EAW81454 EAW81455 EAW81456 EAW81457 Q6IN85 AB095930 BAC23106 AF113213 AAG39284 AI608781 AK000714 BAA91338 AK001885 BAA91960 AK024297 BAB14877 AL832921 CAH10634 BC018617 BC022778 BC028088 AAH28088 BC038932 AAH38932 BC072409 AAH72409 BM147425 BX248247 CAD62575 XM_005267842 XP_005267899 XM_006720194 XP_006720257 XM_011536936 XP_011535238 XR_245703 XR_943491 NM_017936 NM_032560 NM_001284280 NP_001271209 NM_001284281 NP_001271210
Function Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:18487071}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18487071}. Nucleus {ECO:0000269|PubMed:18487071}. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.
Top Pathways Glucagon signaling pathway

Human Smek1 full length protein - ab163173 from Abcam

Category Protein
Source Wheat germ
Species Human
ab163173 on a 12.5% SDS-PAGE stained with Coomassie Blue.

SMEK1 Antibody Blocking Peptide - LS-E21066 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

SMEK1 Antibody Blocking Peptide - LS-E26438 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human Smek1 Protein - H00055671-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Smek1 Blocking Peptide - NB100-2879PEP from Novus Biologicals

Category Peptide
Prices $129.00
Sizes 250 µl
Species Human

SMEK1/KIAA2010 blocking peptide - GTX88983-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human, Mouse, Dog, Rat

SMEK1 Blocking Peptide - 33R-10292 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

SMEK1 Peptide - AC21-1277-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

SMEK1 - H00055671-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

SMEK1 - H00055671-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

Smek1 Peptide - 46-386P from ProSci

Category Peptide
Species Human

SMEK1 fusion protein - ag12810 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

SMEK1 fusion protein - ag5070 from Proteintech Group

Category Protein
Source E. coli-derived, PET28a
Species Human

SMEK1 Protein - abx163566 from Abbexa

Category Protein
Species Human, Mouse, Rat

SMEK1/KIAA2010, Peptide - MBS426139 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human, Mouse, Rat, Dog

Smek1 Recombinant Protein Antigen - NBP1-84664PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

SMEK1 Peptide, Human - M34GP14748H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Smek1 Recombinant Protein Antigen - NBP2-56478PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK1), partial, Recombinant Protein - MBS1367101 from MyBioSource

Category Protein
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

SMEK1 Immunizing peptide - orb16858 from Biorbyt

Category Peptide
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