SMEK1

Gene Symbol SMEK1
Entrez Gene 55671
Alt Symbol FLFL1, KIAA2010, MSTP033, PP4R3A, smk-1, smk1
Species Human
Gene Type protein-coding
Description SMEK homolog 1, suppressor of mek1 (Dictyostelium)
Other Description serine/threonine-protein phosphatase 4 regulatory subunit 3A
Swissprots Q86YI7 Q6IN85 Q9NV01 Q9H7U8 Q9H3F1 Q86U23 Q9NWP1 Q69YK6 Q8IVG1
Accessions EAW81452 EAW81453 EAW81454 EAW81455 EAW81456 EAW81457 Q6IN85 AB095930 BAC23106 AF113213 AAG39284 AI608781 AK000714 BAA91338 AK001885 BAA91960 AK024297 BAB14877 AL832921 CAH10634 BC018617 BC022778 BC028088 AAH28088 BC038932 AAH38932 BC072409 AAH72409 BM147425 BX248247 CAD62575 XM_005267842 XP_005267899 XM_006720194 XP_006720257 XM_011536936 XP_011535238 XR_245703 XR_943491 NM_017936 NM_032560 NM_001284280 NP_001271209 NM_001284281 NP_001271210
Function Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:18487071}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18487071}. Nucleus {ECO:0000269|PubMed:18487071}. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.
Top Pathways Glucagon signaling pathway

SMEK1 CRISPR/Cas9 KO Plasmid (h) - sc-412572 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMEK1 HDR Plasmid (h) - sc-412572-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMEK1 Double Nickase Plasmid (h) - sc-412572-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMEK1 Double Nickase Plasmid (h2) - sc-412572-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMEK1 CRISPR Activation Plasmid (h) - sc-412572-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMEK1 CRISPR Activation Plasmid (h2) - sc-412572-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMEK1 Lentiviral Activation Particles (h) - sc-412572-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMEK1 Lentiviral Activation Particles (h2) - sc-412572-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMEK1 siRNA (h) - sc-92227 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMEK1 shRNA Plasmid (h) - sc-92227-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMEK1 shRNA (h) Lentiviral Particles - sc-92227-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smek1 RNAi - H00055671-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU075241 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19786 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19786 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08624 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08624

SMEK1 siRNA (Human) - CRJ0823 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Smek1 RNAi - H00055671-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

SMEK1 - MBS828881 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SMEK1 (NM_032560.4) - SHH413376 from Creative biogene

Category siRNA
Species Reactivities Human

Human SMEK1 siRNA - orb271324 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMEK1 shRNA Plasmid (Human) - CHJ0823 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SMEK1 miRNA 3'UTR clone - MiUTR1H-09660 from Creative biogene

Species Reactivities Human
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