XRCC6

Gene Symbol	XRCC6
Entrez Gene	2547
Alt Symbol	CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Species	Human
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 6
Other Description	5'-dRP lyase Ku70|5'-deoxyribose-5-phosphate lyase Ku70|70 kDa subunit of Ku antigen|ATP-dependent DNA helicase 2 subunit 1|ATP-dependent DNA helicase II 70 kDa subunit|ATP-dependent DNA helicase II, 70 kDa subunit|CTC box binding factor 75 kDa subunit|CTC box-binding factor 75 kDa subunit|DNA repair protein XRCC6|Ku autoantigen p70 subunit|Ku autoantigen, 70kDa|X-ray repair cross-complementing protein 6|lupus Ku autoantigen protein p70|thyroid autoantigen 70kD (Ku antigen)|thyroid autoantigen 70kDa (Ku antigen)|thyroid-lupus autoantigen p70
Swissprots	Q9UCQ3 Q6FG89 P12956 B1AHC8 Q9UCQ2
Accessions	AAW34364 CAL00149 CAN36299 CBX87167 EAW60446 EAW60447 EAW60448 P12956 AK055786 BAG51575 AK293439 BAG56943 AK304580 BAG65368 AK315618 BAG37986 BC001583 BC008343 AAH08343 BC010034 AAH10034 BC012154 AAH12154 BC018259 AAH18259 BC072449 AAH72449 BI222708 BQ217843 BU584415 BU751953 BU902323 CD683757 CR456492 CAG30378 CR542219 CAG47015 CU013089 CAK54520 CU013377 CAK54819 DA647513 DA718140 DB057280 DC383335 DC386009 EU446892 ABZ92421 EU831485 ACE87172 EU831572 ACE86491 J04607 AAA61177 J04611 AAA51733 M32865 AAA36155 S38729 AAB22381 NM_001288976 NP_001275905 NM_001288977 NP_001275906 NM_001288978 NP_001275907 NM_001469 NP_001460
Function	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-d
Subcellular Location	Nucleus {ECO:0000269|PubMed:22442688}. Chromosome {ECO:0000269|PubMed:22442688}.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rabbit anti-Ku70 Antibody, Affinity Purified - PLA0263 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Mouse/Human XRCC6 / Ku70 ELISA Kit (Cell-Based ELISA) - LS-F2990 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.312-20 ng/ml

Mouse/Human Phospho-XRCC6 / Ku70 (Ser5) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1150 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.312-20 ng/ml

Mouse/Human/Rat XRCC6 / Ku70 ELISA Kit (Cell-Based ELISA) - LS-F2113 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.312-20 ng/ml

Mouse XRCC6 / Ku70 ELISA Kit (Sandwich ELISA) - LS-F7950 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.107 ng/ml Range 0.312-20 ng/ml

Human XRCC6 / Ku70 ELISA Kit (Sandwich ELISA) - LS-F4618 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.312-20 ng/ml

X-Ray Repair Cross Complementing 6 (XRCC6), Human, ELISA Kit - SEA316Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.112ng/mL Range 0.312-20ng/mL

X-Ray Repair Cross Complementing 6 (XRCC6), Human, CLIA Kit - SCA316Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 0.101ng/mL Range 0.312-20ng/mL

XRCC6 (Human) IP-WB Antibody Pair - H00002547-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Ku70/XRCC6 Colorimetric Cell-Based ELISA Kit - CB5411 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

XRCC6 Colorimetric Cell-Based ELISA - CB5760 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Ku70/XRCC6 (Phospho-Ser5) Colorimetric Cell-Based ELISA Kit - CBP1135 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

ELISA Kit for X-Ray Repair Cross Complementing 6 (XRCC6) - SEA316Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.121ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

CLIA Kit for X-Ray Repair Cross Complementing 6 (XRCC6) - SCA316Hu from Uscn Life Science Inc. Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 11.9pg/mL. Range 27.43-20000pg/mL The standard curve concentrations used for the CLIA’s were 20000pg/mL, 6666.67pg/mL, 2222.22pg/mL, 740.74pg/mL, 246.91pg/mL, 82.3pg/mL, 27.43pg/mL

ELISA Kit for X-Ray Repair Cross Complementing 6 (XRCC6) - SEA316Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.107ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

CLIA Kit for X-Ray Repair Cross Complementing 6 (XRCC6) - SCA316Mu from Uscn Life Science Inc. Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 4.96pg/mL. Range 13.72-10000pg/mL The standard curve concentrations used for the CLIA’s were 10000pg/mL, 3333.33pg/mL, 1111.11pg/mL, 370.37pg/mL, 123.46pg/mL, 41.15pg/mL, 13.72pg/mL

X-Ray Repair Cross Complementing 5, ELISA Kit - MBS075019 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Ray Repair Cross Complementing 5, ELISA Kit - MBS086550 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Ray Repair Cross Complementing 5, ELISA Kit - MBS049723 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Ray Repair Cross Complementing 5, ELISA Kit - MBS079691 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Ray Repair Cross Complementing 5, ELISA Kit - MBS047954 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Ray Repair Cross Complementing 5, ELISA Kit - MBS047453 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Ray Repair Cross Complementing 5, ELISA Kit - MBS056926 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Ray Repair Cross Complementing 5, ELISA Kit - MBS055918 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

X-Ray Repair Cross Complementing 5, ELISA Kit - MBS068989 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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