XRCC6

Gene Symbol	XRCC6
Entrez Gene	2547
Alt Symbol	CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Species	Human
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 6
Other Description	5'-dRP lyase Ku70|5'-deoxyribose-5-phosphate lyase Ku70|70 kDa subunit of Ku antigen|ATP-dependent DNA helicase 2 subunit 1|ATP-dependent DNA helicase II 70 kDa subunit|ATP-dependent DNA helicase II, 70 kDa subunit|CTC box binding factor 75 kDa subunit|CTC box-binding factor 75 kDa subunit|DNA repair protein XRCC6|Ku autoantigen p70 subunit|Ku autoantigen, 70kDa|X-ray repair cross-complementing protein 6|lupus Ku autoantigen protein p70|thyroid autoantigen 70kD (Ku antigen)|thyroid autoantigen 70kDa (Ku antigen)|thyroid-lupus autoantigen p70
Swissprots	Q9UCQ3 Q6FG89 P12956 B1AHC8 Q9UCQ2
Accessions	AAW34364 CAL00149 CAN36299 CBX87167 EAW60446 EAW60447 EAW60448 P12956 AK055786 BAG51575 AK293439 BAG56943 AK304580 BAG65368 AK315618 BAG37986 BC001583 BC008343 AAH08343 BC010034 AAH10034 BC012154 AAH12154 BC018259 AAH18259 BC072449 AAH72449 BI222708 BQ217843 BU584415 BU751953 BU902323 CD683757 CR456492 CAG30378 CR542219 CAG47015 CU013089 CAK54520 CU013377 CAK54819 DA647513 DA718140 DB057280 DC383335 DC386009 EU446892 ABZ92421 EU831485 ACE87172 EU831572 ACE86491 J04607 AAA61177 J04611 AAA51733 M32865 AAA36155 S38729 AAB22381 NM_001288976 NP_001275905 NM_001288977 NP_001275906 NM_001288978 NP_001275907 NM_001469 NP_001460
Function	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-d
Subcellular Location	Nucleus {ECO:0000269|PubMed:22442688}. Chromosome {ECO:0000269|PubMed:22442688}.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Ku-70 CRISPR/Cas9 KO Plasmid (h) - sc-400378 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ku-70 HDR Plasmid (h) - sc-400378-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ku-70 Double Nickase Plasmid (h) - sc-400378-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ku-70 Double Nickase Plasmid (h2) - sc-400378-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ku-70 CRISPR Activation Plasmid (h) - sc-400378-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ku-70 CRISPR Activation Plasmid (h2) - sc-400378-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ku-70 Lentiviral Activation Particles (h) - sc-400378-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ku-70 Lentiviral Activation Particles (h2) - sc-400378-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ku-70 siRNA (h) - sc-29383 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ku-70 shRNA Plasmid (h) - sc-29383-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ku-70 shRNA (h) Lentiviral Particles - sc-29383-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ku70/XRCC6 RNAi - H00002547-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU113911 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1990 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1990 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01039 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr01039

XRCC6 siRNA (Human) - CRH1686 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

XRCC6 - MBS8226448 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human XRCC6 (NM_001469.3) - SHH448140 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human XRCC6(NM_001469.3) - SHL139140 from Creative biogene Category siRNA Species Reactivities Human

XRCC6 shRNA Plasmid (Human) - CHH1686 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

XRCC6 miRNA 3'UTR clone - MiUTR1H-11322 from Creative biogene Species Reactivities Human

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