XRCC6

Gene Symbol	XRCC6
Entrez Gene	2547
Alt Symbol	CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Species	Human
Gene Type	protein-coding
Description	X-ray repair complementing defective repair in Chinese hamster cells 6
Other Description	5'-dRP lyase Ku70|5'-deoxyribose-5-phosphate lyase Ku70|70 kDa subunit of Ku antigen|ATP-dependent DNA helicase 2 subunit 1|ATP-dependent DNA helicase II 70 kDa subunit|ATP-dependent DNA helicase II, 70 kDa subunit|CTC box binding factor 75 kDa subunit|CTC box-binding factor 75 kDa subunit|DNA repair protein XRCC6|Ku autoantigen p70 subunit|Ku autoantigen, 70kDa|X-ray repair cross-complementing protein 6|lupus Ku autoantigen protein p70|thyroid autoantigen 70kD (Ku antigen)|thyroid autoantigen 70kDa (Ku antigen)|thyroid-lupus autoantigen p70
Swissprots	Q9UCQ3 Q6FG89 P12956 B1AHC8 Q9UCQ2
Accessions	AAW34364 CAL00149 CAN36299 CBX87167 EAW60446 EAW60447 EAW60448 P12956 AK055786 BAG51575 AK293439 BAG56943 AK304580 BAG65368 AK315618 BAG37986 BC001583 BC008343 AAH08343 BC010034 AAH10034 BC012154 AAH12154 BC018259 AAH18259 BC072449 AAH72449 BI222708 BQ217843 BU584415 BU751953 BU902323 CD683757 CR456492 CAG30378 CR542219 CAG47015 CU013089 CAK54520 CU013377 CAK54819 DA647513 DA718140 DB057280 DC383335 DC386009 EU446892 ABZ92421 EU831485 ACE87172 EU831572 ACE86491 J04607 AAA61177 J04611 AAA51733 M32865 AAA36155 S38729 AAB22381 NM_001288976 NP_001275905 NM_001288977 NP_001275906 NM_001288978 NP_001275907 NM_001469 NP_001460
Function	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-d
Subcellular Location	Nucleus {ECO:0000269|PubMed:22442688}. Chromosome {ECO:0000269|PubMed:22442688}.
Top Pathways	Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ku70 + Ku80 protein fragment - ab73790 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human Ku70 full length protein - ab132938 from Abcam Category Protein Source Wheat germ Species Human

Human Ku70 peptide - ab92421 from Abcam Category Peptide

XRCC6 / Ku70 Antibody Blocking Peptide - LS-E12062 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XRCC6 / Ku70 Antibody Blocking Peptide - LS-E7729 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XRCC6 / Ku70 Antibody Blocking Peptide - LS-E7730 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XRCC6 / Ku70 Antibody Blocking Peptide - LS-E8451 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

XRCC6 / Ku70 Antibody Blocking Peptide - LS-E26372 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Ku70/XRCC6 Protein - H00002547-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Ku70/XRCC6 Recombinant Protein - H00002547-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Ku70/XRCC6 Blocking Peptide - NBP1-41094PEP from Novus Biologicals Category Peptide Prices $199.00 Sizes 50 µg Species Human

XRCC6-Antibody-Center-Blocking-peptide - BP5089c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

XRCC6-Antibody-C-term-Blocking-Peptide - BP5089b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Ku70-Antibody-Center-Blocking-Peptide - BP6775c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Ku70 blocking peptide - GTX89026-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Ku P70/P80 Protein (OPPA01309) - OPPA01309 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Sf9 Insect Cells

Human XRCC6 protein - orb245092 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

XRCC6 peptide - orb219087 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Monkey

G22P1 Blocking Peptide - 33R-6438 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

G22P1 Blocking Peptide - 33R-6687 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Ku70 Blocking Peptide - abx062644 from Abbexa Category Peptide Species Human, Monkey

Ku70 Blocking Peptide - abx062645 from Abbexa Category Peptide Species Human, Monkey

Ku70 Blocking Peptide - abx062118 from Abbexa Category Peptide Species Human, Monkey

Ku70 Peptide - AC21-1207-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

XRCC6 / Ku70 - H00002547-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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