XRCC6

Gene Symbol XRCC6
Entrez Gene 2547
Alt Symbol CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Species Human
Gene Type protein-coding
Description X-ray repair complementing defective repair in Chinese hamster cells 6
Other Description 5'-dRP lyase Ku70|5'-deoxyribose-5-phosphate lyase Ku70|70 kDa subunit of Ku antigen|ATP-dependent DNA helicase 2 subunit 1|ATP-dependent DNA helicase II 70 kDa subunit|ATP-dependent DNA helicase II, 70 kDa subunit|CTC box binding factor 75 kDa subunit|CTC box-binding factor 75 kDa subunit|DNA repair protein XRCC6|Ku autoantigen p70 subunit|Ku autoantigen, 70kDa|X-ray repair cross-complementing protein 6|lupus Ku autoantigen protein p70|thyroid autoantigen 70kD (Ku antigen)|thyroid autoantigen 70kDa (Ku antigen)|thyroid-lupus autoantigen p70
Swissprots Q9UCQ3 Q6FG89 P12956 B1AHC8 Q9UCQ2
Accessions AAW34364 CAL00149 CAN36299 CBX87167 EAW60446 EAW60447 EAW60448 P12956 AK055786 BAG51575 AK293439 BAG56943 AK304580 BAG65368 AK315618 BAG37986 BC001583 BC008343 AAH08343 BC010034 AAH10034 BC012154 AAH12154 BC018259 AAH18259 BC072449 AAH72449 BI222708 BQ217843 BU584415 BU751953 BU902323 CD683757 CR456492 CAG30378 CR542219 CAG47015 CU013089 CAK54520 CU013377 CAK54819 DA647513 DA718140 DB057280 DC383335 DC386009 EU446892 ABZ92421 EU831485 ACE87172 EU831572 ACE86491 J04607 AAA61177 J04611 AAA51733 M32865 AAA36155 S38729 AAB22381 NM_001288976 NP_001275905 NM_001288977 NP_001275906 NM_001288978 NP_001275907 NM_001469 NP_001460
Function Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. 5'-d
Subcellular Location Nucleus {ECO:0000269|PubMed:22442688}. Chromosome {ECO:0000269|PubMed:22442688}.
Top Pathways Non-homologous end-joining

XRCC6-Over-expression-Lysate - LY10971a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag XRCC6 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the XRCC6 gene

G22P1 HEK293 Cell Transient Overexpression Lysate (Non-Denatured) - L105T6 from Acris Antibodies

Category Cell Lysate
Prices $290.00
Sizes 100 µg

XRCC6 293 Cell Lysate - 400567 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Species Hamster

Ku70/XRCC6 Overexpression Lysate (Native) - NBL1-17919 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Ku70 Overexpression Lysate (Adult Normal) [NBL1-17919] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Ku70.

Ku-70 (h): 293T Lysate - sc-111431 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Ku-70 (h2): 293 Lysate - sc-112733 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Ku-70 (h2): 293T Lysate - sc-128972 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Ku-70 (h5): 293T Lysate - sc-177443 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

XRCC6 Over-expression Lysate Product - GWB-9DBEE4 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human XRCC6 Knockdown Stable Cell Line - CSC-DC017598 from Creative biogene

Category Cell Line
Species Human
Search more