IL10RB

Gene Symbol IL10RB
Entrez Gene 3588
Alt Symbol CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2
Species Human
Gene Type protein-coding
Description interleukin 10 receptor, beta
Other Description IL-10 receptor subunit beta|IL-10R subunit 2|IL-10R subunit beta|IL-10RB|cytokine receptor class-II CRF2-4|cytokine receptor class-II member 4|cytokine receptor family 2 member 4|cytokine receptor family II, member 4|interleukin-10 receptor subunit 2|interleukin-10 receptor subunit beta
Swissprots Q9BUU4 Q08334
Accessions AAA86872 AAP72016 EAX09840 EAX09841 Q08334 AI025402 AK124057 BAC85761 AK299961 BAG61787 AK313348 AU133530 BC001903 AAH01903 BT009777 AAP88779 DQ892552 ABM83478 DQ895763 ABM86689 JN591378 AEX60807 Z17227 CAA78933 NM_000628 NP_000619
Function Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:15123776}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Top Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Toxoplasmosis, Tuberculosis, Epstein-Barr virus infection

IL-10Rβ (C-17) - sc-69574 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-10Rβ (C-17): sc-69574. Western blot analysis of IL-10Rβ expression in U-937 whole cell lysate.

IL-10Rβ (H-300) - sc-98717 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-10Rβ (H-300): sc-98717. Western blot analysis of IL-10Rβ expression in HeLa whole cell lysate.

IL-10Rβ (G-19) - sc-69576 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-10Rβ (G-19): sc-69576. Western blot analysis of IL-10Rβ expression in Jurkat whole cell lysate.

IL-10Rβ (S-17) - sc-69579 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-10Rβ (S-17): sc-69579. Western blot analysis of IL-10Rβ expression in Jurkat whole cell lysate.

IL-10Rβ (Y-18) - sc-69580 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-10Rβ (Y-18): sc-69580. Western blot analysis of IL-10Rβ expression in Jurkat whole cell lysate.

Anti-IL10RB antibody - ab106282 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL10RB antibody (ab106282) at 1/1000 dilutionLane 1 : Human fetal heart lysateLane 2 : Human fetal liver lysateLane 3 : Human fetal muscle lysateLane 4 : Human fetal kidney lysate

Anti-IL10RB antibody - ab172006 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL10RB antibody (ab172006) at 1 µg/mlLane 1 : IL10RB transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Rabbit IgG (H+L)-Peroxidase conjugated at 1/7500 dilutiondeveloped using the ECL technique

Anti-IL10RB antibody - ab172015 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-IL10RB antibody (ab172015) at 1 µg/mlLane 1 : IL10RB transfected lysateLane 2 : Non-transfected lysateLysates/proteins at 15 µl per lane.

Anti-IL10RB antibody - ab172024 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-IL10RB antibody (ab172024) at 1 µg/mlLane 1 : IL10RB transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-IL10RB antibody [3F9] - ab33401 from Abcam

Prices $359.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 3F9

Anti-IL10RB antibody [MM0360-8R24] - ab89884 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0360-8R24
Overlay histogram showing Jurkat cells stained with ab89884 (red line). The cells were fixed with 80% methanol (5 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab89884, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-IL10RB Antibody - LS-C130245 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-IL10RB Antibody (aa21-220, Biotin) - LS-C125811 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-IL10RB Antibody (aa21-220, clone 12K115, PerCP) - LS-C182889 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Rat
Clonality Monoclonal
Clone 12K115

Anti-IL10RB Antibody (aa20-220, clone 11n101, APC) - LS-C184817 from LifeSpan Bioscience

Prices $590.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal
Clone 11n101

Anti-IL10RB Antibody (aa42-218, Biotin) - LS-C297163 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL10RB Antibody (aa87-243, Biotin) - LS-C300780 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL10RB Antibody (aa87-243, FITC) - LS-C304964 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL10RB Antibody - LS-C308439 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-IL10RB Antibody (aa42-218, FITC) - LS-C303959 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL10RB Antibody - LS-C310732 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL10RB Antibody - LS-C310731 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IL10RB Antibody (aa87-243) - LS-C294816 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL10RB / IL-10R2.

Anti-IL10RB Antibody (aa42-218) - LS-C294817 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL10RB / IL-10R2.

IL-10 R beta Antibody [Unconjugated] - AF874 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Recombinant Human IL‑10 (Catalog # 217-IL) inhibits IL‑1 beta secretion in LPS-activated human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner (orange line), as measured by the Human IL‑1 beta /IL‑1F2 Quantikine ELISA Kit (Catalog # DLB50).IL‑1 beta secretion inhibited by Recombinant Human IL‑10 (0.25 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL‑10 R beta Antigen Affinity-purified Polyclonal Antibody (Catalog # AF874). The ND50 is typically 2-6 µg/mL in the presence of LPS (0.25 ng/mL).
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