| Gene Symbol |
IL10RB
|
| Entrez Gene |
3588
|
| Alt Symbol |
CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 10 receptor, beta
|
| Other Description |
IL-10 receptor subunit beta|IL-10R subunit 2|IL-10R subunit beta|IL-10RB|cytokine receptor class-II CRF2-4|cytokine receptor class-II member 4|cytokine receptor family 2 member 4|cytokine receptor family II, member 4|interleukin-10 receptor subunit 2|interleukin-10 receptor subunit beta
|
| Swissprots |
Q9BUU4 Q08334
|
| Accessions |
AAA86872 AAP72016 EAX09840 EAX09841 Q08334 AI025402 AK124057 BAC85761 AK299961 BAG61787 AK313348 AU133530 BC001903 AAH01903 BT009777 AAP88779 DQ892552 ABM83478 DQ895763 ABM86689 JN591378 AEX60807 Z17227 CAA78933 NM_000628 NP_000619
|
| Function |
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:15123776}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Toxoplasmosis, Tuberculosis, Epstein-Barr virus infection
|