| Gene Symbol |
ARTN
|
| Entrez Gene |
9048
|
| Alt Symbol |
ENOVIN, EVN, NBN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
artemin
|
| Other Description |
neublastin|neurotrophic factor
|
| Swissprots |
Q6P6A3 D3DPY3 Q5T4W7 D3DPY1 O96030 O95441
|
| Accessions |
AAD13109 AAD13110 CAB52396 EAX07074 EAX07075 EAX07076 EAX07077 EAX07078 EAX07079 EAX07080 EAX07081 Q5T4W7 AF109401 AAC98690 AF120274 AAD21075 BC062375 AAH62375 XM_006711024 XP_006711087 XM_011542402 XP_011540704 NM_001136215 NP_001129687 NM_057090 NP_476431 NM_057091 NP_476432 NM_003976 NM_057160
|
| Function |
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. {ECO:0000269|PubMed:10583383, ECO:0000269|PubMed:9883723}.
|
| Subcellular Location |
Secreted {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta, pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain. {ECO:0000269|PubMed:10583383, ECO:0000269|PubMed:9883723}.
|