Gene Symbol | ARTN |
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Entrez Gene | 9048 |
Alt Symbol | ENOVIN, EVN, NBN |
Species | Human |
Gene Type | protein-coding |
Description | artemin |
Other Description | neublastin|neurotrophic factor |
Swissprots | Q6P6A3 D3DPY3 Q5T4W7 D3DPY1 O96030 O95441 |
Accessions | AAD13109 AAD13110 CAB52396 EAX07074 EAX07075 EAX07076 EAX07077 EAX07078 EAX07079 EAX07080 EAX07081 Q5T4W7 AF109401 AAC98690 AF120274 AAD21075 BC062375 AAH62375 XM_006711024 XP_006711087 XM_011542402 XP_011540704 NM_001136215 NP_001129687 NM_057090 NP_476431 NM_057091 NP_476432 NM_003976 NM_057160 |
Function | Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. {ECO:0000269|PubMed:10583383, ECO:0000269|PubMed:9883723}. |
Subcellular Location | Secreted {ECO:0000250}. |
Tissue Specificity | Ubiquitous. Expressed at high levels in peripheral tissues including prostate, placenta, pancreas, heart, kidney, pituitary gland, lung and testis. Expressed at low levels in the brain. {ECO:0000269|PubMed:10583383, ECO:0000269|PubMed:9883723}. |
Artn CRISPR/Cas9 KO Plasmid (h) - sc-405922 from Santa Cruz Biotechnology
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Artn HDR Plasmid (h) - sc-405922-HDR from Santa Cruz Biotechnology
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Artn Double Nickase Plasmid (h) - sc-405922-NIC from Santa Cruz Biotechnology
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Artn Double Nickase Plasmid (h2) - sc-405922-NIC-2 from Santa Cruz Biotechnology
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Artn CRISPR Activation Plasmid (h) - sc-405922-ACT from Santa Cruz Biotechnology
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Artn CRISPR Activation Plasmid (h2) - sc-405922-ACT-2 from Santa Cruz Biotechnology
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Artn Lentiviral Activation Particles (h) - sc-405922-LAC from Santa Cruz Biotechnology
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Artn Lentiviral Activation Particles (h2) - sc-405922-LAC-2 from Santa Cruz Biotechnology
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Artn siRNA (h) - sc-41966 from Santa Cruz Biotechnology
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Artn shRNA Plasmid (h) - sc-41966-SH from Santa Cruz Biotechnology
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Artn shRNA (h) Lentiviral Particles - sc-41966-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU092211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3553 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3553 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04032 from Sigma-Aldrich
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ARTN siRNA (Human) - CRH5969 from Cohesion Biosciences
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ARTN - MBS8225413 from MyBioSource
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shRNA set against Human ARTN (NM_001136215.1) - SHH240990 from Creative biogene
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Human ARTN siRNA - orb266471 from Biorbyt
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ARTN shRNA Plasmid (Human) - CHH5969 from Cohesion Biosciences
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ARTN miRNA 3'UTR clone - MiUTR3H-06351 from Creative biogene
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ARTN miRNA 3'UTR clone - MiUTR3H-06352 from Creative biogene
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ARTN miRNA 3'UTR clone - MiUTR3H-06353 from Creative biogene
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