| Gene Symbol |
NUDT15
|
| Entrez Gene |
55270
|
| Alt Symbol |
MTH2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nudix (nucleoside diphosphate linked moiety X)-type motif 15
|
| Other Description |
8-oxo-dGTPase NUDT15|mutT homolog 2|probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15|probable 8-oxo-dGTP diphosphatase NUDT15
|
| Swissprots |
Q6P2C9 A2RUR6 Q32Q27 Q9NV35
|
| Accessions |
EAX08782 Q9NV35 AK001818 BAA91925 BC050698 BC064607 AAH64607 BC107875 AAI07876 BC133015 AAI33016 BC133017 AAI33018 BU622058 NM_001304745 NP_001291674 NM_018283 NP_060753
|
| Function |
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA. {ECO:0000250, ECO:0000269|PubMed:19419956, ECO:0000269|PubMed:22556419}.
|