Gene Symbol | NUDT15 |
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Entrez Gene | 55270 |
Alt Symbol | MTH2 |
Species | Human |
Gene Type | protein-coding |
Description | nudix (nucleoside diphosphate linked moiety X)-type motif 15 |
Other Description | 8-oxo-dGTPase NUDT15|mutT homolog 2|probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15|probable 8-oxo-dGTP diphosphatase NUDT15 |
Swissprots | Q6P2C9 A2RUR6 Q32Q27 Q9NV35 |
Accessions | EAX08782 Q9NV35 AK001818 BAA91925 BC050698 BC064607 AAH64607 BC107875 AAI07876 BC133015 AAI33016 BC133017 AAI33018 BU622058 NM_001304745 NP_001291674 NM_018283 NP_060753 |
Function | Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA. {ECO:0000250, ECO:0000269|PubMed:19419956, ECO:0000269|PubMed:22556419}. |
NUDT15 CRISPR/Cas9 KO Plasmid (h) - sc-410005 from Santa Cruz Biotechnology
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NUDT15 HDR Plasmid (h) - sc-410005-HDR from Santa Cruz Biotechnology
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NUDT15 Double Nickase Plasmid (h) - sc-410005-NIC from Santa Cruz Biotechnology
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NUDT15 Double Nickase Plasmid (h2) - sc-410005-NIC-2 from Santa Cruz Biotechnology
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NUDT15 CRISPR Activation Plasmid (h) - sc-410005-ACT from Santa Cruz Biotechnology
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NUDT15 CRISPR Activation Plasmid (h2) - sc-410005-ACT-2 from Santa Cruz Biotechnology
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NUDT15 Lentiviral Activation Particles (h) - sc-410005-LAC from Santa Cruz Biotechnology
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NUDT15 Lentiviral Activation Particles (h2) - sc-410005-LAC-2 from Santa Cruz Biotechnology
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NUDT15 siRNA (h) - sc-75972 from Santa Cruz Biotechnology
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NUDT15 shRNA Plasmid (h) - sc-75972-SH from Santa Cruz Biotechnology
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NUDT15 shRNA (h) Lentiviral Particles - sc-75972-V from Santa Cruz Biotechnology
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NUDT15 RNAi - H00055270-R01 from Novus Biologicals
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MISSION® esiRNA - EHU042631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15593 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15593 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09613 from Sigma-Aldrich
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NUDT15 siRNA (Human) - CRJ0611 from Cohesion Biosciences
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shRNA set against Human NUDT15 (NM_018283.1) - SHH356072 from Creative biogene
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shRNA set against Human NUDT15(NM_018283.1) - SHR025616 from Creative biogene
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Human NUDT15 siRNA - orb271112 from Biorbyt
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NUDT15 shRNA Plasmid (Human) - CHJ0611 from Cohesion Biosciences
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NUDT15 miRNA 3'UTR clone - MiUTR1H-06968 from Creative biogene
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