DSTYK

Gene Symbol	DSTYK
Entrez Gene	25778
Alt Symbol	CAKUT1, DustyPK, HDCMD38P, RIP5, RIPK5
Species	Human
Gene Type	protein-coding
Description	dual serine/threonine and tyrosine protein kinase
Other Description	RIP-homologous kinase|dusty PK|dusty protein kinase|receptor-interacting serine/threonine-protein kinase 5|sgK496|sugen kinase 496
Swissprots	B7ZL64 Q86Y03 O75060 Q6P997 Q5RKT0 Q6IN87 Q9P1S5 Q6XUX3 Q17R94
Accessions	EAW91540 EAW91541 EAW91542 EAW91543 EAW91544 Q6XUX3 AB007941 BAA32317 AF068286 AAF65505 AJ420466 AK298011 BAG60315 AY208850 AAP42418 AY429674 AAS55390 BC018303 BC048204 AAH48204 BC053627 AAH53627 BC060870 AAH60870 BC072406 AAH72406 BC117411 AAI17412 BC143603 AAI43604 BF836208 BI494979 BI494980 BM685960 BQ946417 BU168830 BU170290 BU528180 CA950005 EU832787 ACE87798 GQ129280 ACT64414 XM_011509392 XP_011507694 XM_011509393 XP_011507695 XM_011509394 XP_011507696 NM_015375 NP_056190 NM_199462 NP_955749
Function	Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}. Cell membrane {ECO:0000250|UniProtKB:Q6XUX1}. Apical cell membrane {ECO:0000269|PubMed:23862974}. Basolateral cell membrane {ECO:0000269|PubMed:23862974}. Cell junction {ECO:0000250|UniProtKB:Q6XUX1}. Note=Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. {ECO:0000250|UniProtKB:Q6XUX1, ECO:0000269|PubMed:23862974}.
Tissue Specificity	Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DSTYK Gene cDNA Clone - orb142914 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human DSTYK Gene cDNA clone plasmid - HG15549-G from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15549-CY from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15549-NF from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15549-CF from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15549-NM from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15549-NY from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15549-CM from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15549-ACG from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15549-ANG from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid - HG15549-UT from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15549-ACR from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15549-ANR from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, N-His tag - HG15549-NH from Sino Biological Species Human

Human DSTYK/RIPK5 Gene ORF cDNA clone expression plasmid, C-His tag - HG15549-CH from Sino Biological Species Human

Human DSTYK ORF Clone (BC053627) - CDCS418465 from Creative biogene Species Human Accession Q6XUX3

Human DSTYK ORF Clone (BC117411) - CDCS418466 from Creative biogene Species Human Accession Q6XUX3

Human DSTYK ORF clone (BC053627) - CDCB158051 from Creative biogene Species Human

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