DSTYK

Gene Symbol DSTYK
Entrez Gene 25778
Alt Symbol CAKUT1, DustyPK, HDCMD38P, RIP5, RIPK5
Species Human
Gene Type protein-coding
Description dual serine/threonine and tyrosine protein kinase
Other Description RIP-homologous kinase|dusty PK|dusty protein kinase|receptor-interacting serine/threonine-protein kinase 5|sgK496|sugen kinase 496
Swissprots B7ZL64 Q86Y03 O75060 Q6P997 Q5RKT0 Q6IN87 Q9P1S5 Q6XUX3 Q17R94
Accessions EAW91540 EAW91541 EAW91542 EAW91543 EAW91544 Q6XUX3 AB007941 BAA32317 AF068286 AAF65505 AJ420466 AK298011 BAG60315 AY208850 AAP42418 AY429674 AAS55390 BC018303 BC048204 AAH48204 BC053627 AAH53627 BC060870 AAH60870 BC072406 AAH72406 BC117411 AAI17412 BC143603 AAI43604 BF836208 BI494979 BI494980 BM685960 BQ946417 BU168830 BU170290 BU528180 CA950005 EU832787 ACE87798 GQ129280 ACT64414 XM_011509392 XP_011507694 XM_011509393 XP_011507695 XM_011509394 XP_011507696 NM_015375 NP_056190 NM_199462 NP_955749
Function Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}. Cell membrane {ECO:0000250|UniProtKB:Q6XUX1}. Apical cell membrane {ECO:0000269|PubMed:23862974}. Basolateral cell membrane {ECO:0000269|PubMed:23862974}. Cell junction {ECO:0000250|UniProtKB:Q6XUX1}. Note=Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. {ECO:0000250|UniProtKB:Q6XUX1, ECO:0000269|PubMed:23862974}.
Tissue Specificity Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}.

RIP5 CRISPR/Cas9 KO Plasmid (h) - sc-404521 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP5 HDR Plasmid (h) - sc-404521-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP5 Double Nickase Plasmid (h) - sc-404521-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP5 Double Nickase Plasmid (h2) - sc-404521-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP5 CRISPR Activation Plasmid (h) - sc-404521-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP5 CRISPR Activation Plasmid (h2) - sc-404521-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP5 Lentiviral Activation Particles (h) - sc-404521-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP5 Lentiviral Activation Particles (h2) - sc-404521-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RIP5 siRNA (h) - sc-88815 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RIP5 shRNA Plasmid (h) - sc-88815-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RIP5 shRNA (h) Lentiviral Particles - sc-88815-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU133351 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1974 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1976 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1975 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN7518 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7518 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DSTYK siRNA (Human) - CRH8490 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RIPK5 RNAi - H00025778-R07 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RIPK5 RNAi - H00025778-R08 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

DSTYK - MBS8239030 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DSTYK (NM_199462.2) - SHH281373 from Creative biogene

Category siRNA
Species Reactivities Human

DSTYK shRNA Plasmid (Human) - CHH8490 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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