DSTYK

Gene Symbol	DSTYK
Entrez Gene	25778
Alt Symbol	CAKUT1, DustyPK, HDCMD38P, RIP5, RIPK5
Species	Human
Gene Type	protein-coding
Description	dual serine/threonine and tyrosine protein kinase
Other Description	RIP-homologous kinase|dusty PK|dusty protein kinase|receptor-interacting serine/threonine-protein kinase 5|sgK496|sugen kinase 496
Swissprots	B7ZL64 Q86Y03 O75060 Q6P997 Q5RKT0 Q6IN87 Q9P1S5 Q6XUX3 Q17R94
Accessions	EAW91540 EAW91541 EAW91542 EAW91543 EAW91544 Q6XUX3 AB007941 BAA32317 AF068286 AAF65505 AJ420466 AK298011 BAG60315 AY208850 AAP42418 AY429674 AAS55390 BC018303 BC048204 AAH48204 BC053627 AAH53627 BC060870 AAH60870 BC072406 AAH72406 BC117411 AAI17412 BC143603 AAI43604 BF836208 BI494979 BI494980 BM685960 BQ946417 BU168830 BU170290 BU528180 CA950005 EU832787 ACE87798 GQ129280 ACT64414 XM_011509392 XP_011507694 XM_011509393 XP_011507695 XM_011509394 XP_011507696 NM_015375 NP_056190 NM_199462 NP_955749
Function	Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}. Cell membrane {ECO:0000250|UniProtKB:Q6XUX1}. Apical cell membrane {ECO:0000269|PubMed:23862974}. Basolateral cell membrane {ECO:0000269|PubMed:23862974}. Cell junction {ECO:0000250|UniProtKB:Q6XUX1}. Note=Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. {ECO:0000250|UniProtKB:Q6XUX1, ECO:0000269|PubMed:23862974}.
Tissue Specificity	Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RIPK5 full length protein - ab89694 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human RIPK5 full length protein - ab161776 from Abcam Category Protein Source Wheat germ Species Human

Human RIPK5 protein fragment - ab161777 from Abcam Category Protein Source Wheat germ Species Human

DSTYK / RIPK5 Antibody Blocking Peptide - LS-E20252 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RIPK5 Protein - H00025778-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RIPK5 Protein - H00025778-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RIPK5 Blocking Peptide - 33R-2341 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RIPK5 / DSTYK - H00025778-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RIPK5 / DSTYK - H00025778-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RIPK5 / DSTYK - H00025778-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RIPK5 / DSTYK - H00025778-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DSTYK fusion protein - Ag13678 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human DSTYK, GST-tagged, Active - DSTYK-419H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human DSTYK - DSTYK-29984TH from Creative Biomart Category Protein

Recombinant Human DSTYK, GST-tagged - DSTYK-12184H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Dual Serine/Threonine And Tyrosine Protein Kinase (DSTYK) - RPG527Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Human Dual serine/threonine and tyrosine protein kinase(DSTYK) ,partial - CSB-YP007213HU CSB-EP007213HU CSB-BP007213HU CSB-MP007213HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RIPK5 / DSTYK (transcript variant 1) - TP309967 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RIPK5 Protein - NBP1-92336PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

RIPK5-Antibody-Center-Blocking-peptide - BP7194c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RIPK5-Antibody-N-term-Blocking-peptide - BP7194a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DSTYK-Blocking-Peptide-N-Term - BP21613a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DSTYK Peptide, Human - M34GP04574H from Creative Peptides Category Peptide Source Synthetic. Species Human

Dual serine/threonine and tyrosine protein kinase (DSTYK), partial, Recombinant Protein - MBS1407691 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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