DSTYK

Gene Symbol DSTYK
Entrez Gene 25778
Alt Symbol CAKUT1, DustyPK, HDCMD38P, RIP5, RIPK5
Species Human
Gene Type protein-coding
Description dual serine/threonine and tyrosine protein kinase
Other Description RIP-homologous kinase|dusty PK|dusty protein kinase|receptor-interacting serine/threonine-protein kinase 5|sgK496|sugen kinase 496
Swissprots B7ZL64 Q86Y03 O75060 Q6P997 Q5RKT0 Q6IN87 Q9P1S5 Q6XUX3 Q17R94
Accessions EAW91540 EAW91541 EAW91542 EAW91543 EAW91544 Q6XUX3 AB007941 BAA32317 AF068286 AAF65505 AJ420466 AK298011 BAG60315 AY208850 AAP42418 AY429674 AAS55390 BC018303 BC048204 AAH48204 BC053627 AAH53627 BC060870 AAH60870 BC072406 AAH72406 BC117411 AAI17412 BC143603 AAI43604 BF836208 BI494979 BI494980 BM685960 BQ946417 BU168830 BU170290 BU528180 CA950005 EU832787 ACE87798 GQ129280 ACT64414 XM_011509392 XP_011507694 XM_011509393 XP_011507695 XM_011509394 XP_011507696 NM_015375 NP_056190 NM_199462 NP_955749
Function Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death. {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}. Cell membrane {ECO:0000250|UniProtKB:Q6XUX1}. Apical cell membrane {ECO:0000269|PubMed:23862974}. Basolateral cell membrane {ECO:0000269|PubMed:23862974}. Cell junction {ECO:0000250|UniProtKB:Q6XUX1}. Note=Detected at apical cell-cell junctions. Colocalized with FGF receptors to the cell membrane (By similarity). Detected in basolateral and apical membranes of all tubular epithelia. {ECO:0000250|UniProtKB:Q6XUX1, ECO:0000269|PubMed:23862974}.
Tissue Specificity Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:17123648, ECO:0000269|PubMed:23862974}.

RIP5 (E-6) - sc-374487 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RIP5 (E-6): sc-374487. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

RIP5 (C-14) - sc-162107 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RIP5 (H-300) - sc-135373 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RIP5 (H-300): sc-135373. Western blot analysis of RIP5 expression in Daudi whole cell lysate.

RIP5 (N-16) - sc-162109 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RIP5 (N-16): sc-162109. Western blot analysis of RIP5 expression in mouse PBL whole cell lysate.

RIP5 (Q-16) - sc-162110 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RIP5 (Q-16): sc-162110. Western blot analysis of RIP5 expression in Daudi whole cell lysate.

Anti-RIPK5 antibody - ab195673 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RIPK5 antibody (ab195673) at 1/500 dilutionLane 1 : HepG2 cell lysateLane 2 : A431 cell lysate

Anti-RIPK5 antibody - ab153997 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RIPK5 antibody (ab153997) at 1/1000 dilutionLane 1 : HepG2 whole cell lysateLane 2 : MOLT4 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-RIPK5 antibody - ab57034 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57034 RIPK5 antibody at 1ug/ml.

Anti-DSTYK / RIPK5 Antibody (C-Terminus) - LS-C111754 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DSTYK / RIPK5 antibody LS-C111754 Western blot of Fetal Spleen lysate.

RIPK5 Antibody - NBP1-32646 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RIPK5 Antibody [NBP1-32646] - Sample (30ug whole cell lysate)A:Hep G2 7. 5% SDS PAGE, antibody diluted at 1:1000.

RIPK5 Antibody - NBP1-92336 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RIPK5 Antibody [NBP1-92336] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

RIPK5 Antibody - NBP1-54845 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RIPK5 Antibody [NBP1-54845] - Human Spleen lysate, concentration 0.2-1 ug/ml.

RIPK5 Antibody - H00025778-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: RIPK5 Antibody [H00025778-B01] - K5 MaxPab polyclonal antibody (B01), Lot # 08067 WULz. Western Blot analysis of RIPK5 expression in human stomach.

RIPK5 Antibody (4B3) - H00025778-M07 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B3

RIPK5 Antibody (4F3) - H00025778-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4F3

RIPK5 Antibody (4D5) - H00025778-M08 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D5

RIPK5 Antibody - H00025778-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: RIPK5 Antibody [H00025778-B01P] - Analysis of DSTYK expression in human stomach.

RIPK5 Antibody (1F9) - H00025778-M06 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F9
Western Blot: RIPK5 Antibody (1F9) [H00025778-M06] - Analysis of DSTYK expression in transfected 293T cell line by DSTYK monoclonal antibody (M06), clone 1F9. Lane 1: DSTYK transfected lysate (Predicted MW: 66.4 KDa). Lane 2: Non-transfected lysate.

Anti-DSTYK antibody produced in rabbit - HPA044140 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DSTYK: <B>Cat. No. HPA044140</B>: Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts and leydig cells).

ANTI-RIPK5 antibody produced in mouse - SAB1412409 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D5
<B>Immunoblotting</B><BR/>Monoclonal Anti-RIPK5: <B>Cat. No. SAB1412409</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.8 kDa using immunogen protein lysate.

Anti-RIPK5 antibody produced in rabbit - SAB2104160 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RIPK5, antibody produced in rabbit: <B>Cat. No. SAB2104160</B>: Immunoblotting analysis of RIPK5 in fetal spleen tissue lysate with RIPK5 anitbody at 1 μg/mL.

Monoclonal Anti-DSTYK antibody produced in mouse - SAB1409063 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F9

Anti-RIPK5 (376-390) antibody produced in rabbit - R7905 from Sigma-Aldrich

Prices $342.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-RIPK5 (376-390) (RB): <B>Cat. No. R7905</B>: Immunofluorescence of HUVEC cells using RIPK5 (376-390) (RB), <B>Cat. No. R7905</B> (red) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used.<BR/>Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Monoclonal Anti-RIPK5 antibody produced in mouse - SAB1404994 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B3
<B>Immunoblotting</B><BR/>Monoclonal Anti-RIPK5: <B>Cat. No. SAB1404994</B>: Antibody concentration: 1 μg/mL. Specific band of ~38.2 kDa using immunogen protein lysate.

Anti-DSTYK antibody produced in mouse - SAB1409064 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DSTYK: <B>Cat. No. SAB1409064</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~105.3 kDa using human stomach lysate.
Search more