GRK1

Gene Symbol GRK1
Entrez Gene 6011
Alt Symbol GPRK1, RHOK, RK
Species Human
Gene Type protein-coding
Description G protein-coupled receptor kinase 1
Other Description rhodopsin kinase
Swissprots Q15835 Q53X14
Accessions AAC97160 AAC97161 AAQ94192 AAT00534 EAX09222 Q15835 AK289912 BAF82601 BC140945 AAI40946 BM702747 BX647503 L77503 AAG50439 U63973 AAB05929 NM_002929 NP_002920
Function Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. {ECO:0000269|PubMed:15946941}.
Subcellular Location Membrane {ECO:0000250|UniProtKB:P28327}; Lipid-anchor {ECO:0000250|UniProtKB:P28327}.
Tissue Specificity Retinal-specific. Expressed in rods and cones cells. {ECO:0000269|PubMed:11717351}.
Top Pathways Endocytosis, Chemokine signaling pathway, Phototransduction

GRK 1 (C-20) - sc-561 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
GRK 1 (C-20): sc-561. Western blot analysis of GRK 1 expression in bovine retina rod outer segment suspension.

GRK 1 (D11) - sc-56910 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GRK 1 (D11): sc-56910. Western blot analysis of GRK 1 expression in Y79 (A) whole cell lysate and mouse retina (B) and mouse retina (C) tissue extracts under reducing (A,B) and non-reducing (C) conditions.

GRK 1 (H-160) - sc-13078 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

GRK 1 (N-13) - sc-84290 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
GRK 1 (N-13): sc-84290. Western blot analysis of GRK 1 expression in MCF7 (A) and HT-1080 (B) whole cell lysates and mouse eye tissue extract (C).

GRK 1 (S-16) - sc-84291 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
GRK 1 (S-16): sc-84291. Western blot analysis of GRK 1 expression in Y79 whole cell lysate (A) and mouse eye tissue extract (B).

Anti-GRK1 (phospho S21) antibody - ab74033 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab74033 at 1/50 dilution staining GRK1 in human brain by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-GRK1 antibody - ab193447 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GRK1 antibody - ab136829 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GRK1 antibody (ab136829) at 1/500 dilution + Jurkat cell lysate at 30 µg

Anti-GRK1 antibody - ab57928 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57928 GRK1 antibody at 1ug/ml.

Anti-GRK1 antibody [D11] - ab2776 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone D11
Immunocytochemistry/Immunofluorescence analysis of GRK1 (green) in murine cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes at room temperature and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were incubated with ab2776 (1:200) overnight in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody for 45 minutes at room temperature in the dark. F-actin (red) was stained with a fluorescent phalloidin and nuclei (blue) were stained with DAPI. Images were taken at a 60X magnification.

Anti-GRK1 antibody [EPR2039(2)] - ab108502 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2039(2)
All lanes : Anti-GRK1 antibody [EPR2039(2)] (ab108502) at 1/1000 dilutionLane 1 : Y79 cell lysateLane 2 : JAR cell lysateLysates/proteins at 10 µg per lane.

Anti-GRK1 antibody [G8] - ab2775 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone G8
Immunocytochemistry/Immunofluorescence analysis of GRK1 (green) in murine cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes at room temperature and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were incubated with ab2775 (1:200) overnight in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody for 45 minutes at room temperature in the dark. F-actin (red) was stained with a fluorescent phalloidin and nuclei (blue) were stained with DAPI. Images were taken at a 60X magnification.

Anti-Rhodopsin Kinase / GRK1 Antibody - LS-C334755 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Y79 cell line, using GRK1 antibody.

Anti-Rhodopsin Kinase / GRK1 Antibody (phospho-Ser21) - LS-C199024 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain, using GRK1 (Phospho-Ser21) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-Rhodopsin Kinase / GRK1 Antibody - LS-C332301 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human esophagus cancer tissue using GRK1 antibody.

Anti-Rhodopsin Kinase / GRK1 Antibody (C-Terminus) - LS-C38881 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Rhodopsin Kinase / GRK1 Antibody (aa343-563) - LS-C75456 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Rhodopsin Kinase / GRK1 Antibody (N-Terminus) - LS-C75457 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Rhodopsin Kinase / GRK1 Antibody (aa401-450) - LS-C135615 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Rhodopsin Kinase / GRK1 antibody Western Blot of Jurkat.

Anti-Rhodopsin Kinase / GRK1 Antibody (Internal, clone EPR2039(2)) - LS-C138476 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2039(2)
Western blot analysis on (A) Y79 and (B) JAR cell lysates using anti-GRK1 antibody.

Anti-Rhodopsin Kinase / GRK1 Antibody (aa6-55) - LS-C117903 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using GRK1 (Ab-21) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-Rhodopsin Kinase / GRK1 Antibody (clone 1G8) - LS-C198087 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G8
Detection limit for recombinant GST tagged GRK1 is approximately 0.3 ng/ml as a capture antibody.

Anti-Rhodopsin Kinase / GRK1 Antibody (C-Terminus, AP) - LS-C277760 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Rhodopsin Kinase / GRK1 Antibody (C-Terminus, APC) - LS-C277762 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Rhodopsin Kinase / GRK1 Antibody (C-Terminus, FITC) - LS-C277763 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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