Gene Symbol | GRK1 |
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Entrez Gene | 6011 |
Alt Symbol | GPRK1, RHOK, RK |
Species | Human |
Gene Type | protein-coding |
Description | G protein-coupled receptor kinase 1 |
Other Description | rhodopsin kinase |
Swissprots | Q15835 Q53X14 |
Accessions | AAC97160 AAC97161 AAQ94192 AAT00534 EAX09222 Q15835 AK289912 BAF82601 BC140945 AAI40946 BM702747 BX647503 L77503 AAG50439 U63973 AAB05929 NM_002929 NP_002920 |
Function | Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. {ECO:0000269|PubMed:15946941}. |
Subcellular Location | Membrane {ECO:0000250|UniProtKB:P28327}; Lipid-anchor {ECO:0000250|UniProtKB:P28327}. |
Tissue Specificity | Retinal-specific. Expressed in rods and cones cells. {ECO:0000269|PubMed:11717351}. |
Top Pathways | Endocytosis, Chemokine signaling pathway, Phototransduction |
Mouse/Human/Rat Phospho-Rhodopsin Kinase / GRK1 (Ser21) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1361 from LifeSpan Bioscience
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Mouse/Human/Rat Rhodopsin Kinase / GRK1 ELISA Kit (Cell-Based ELISA) - LS-F2027 from LifeSpan Bioscience
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GRK1 Colorimetric Cell-Based ELISA Kit - CB5305 from Assay Biotechnology
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GRK1 (Phospho-Ser21) Colorimetric Cell-Based ELISA Kit - CBP1377 from Assay Biotechnology
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G protein-coupled receptor kinase 1, ELISA Kit - MBS9328056 from MyBioSource
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GRK1 ELISA Kit - DEIA-XYA751 from Creative Diagnostics
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GRK1 (Phospho-Ser21) ELISA Kit - DEIA-XYA752 from Creative Diagnostics
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Custom Human GRK1 ELISA - ELH-GRK1-1 from RayBiotech
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Custom Human GRK1 ELISA Kit - orb384611 from Biorbyt
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Human GRK1 ELISA Kit - E015846 from Biobool
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GRK1 Colorimetric Cell-Based ELISA Kit - EKA50262 from Biomatik
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