| Gene Symbol |
GRK1
|
| Entrez Gene |
6011
|
| Alt Symbol |
GPRK1, RHOK, RK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor kinase 1
|
| Other Description |
rhodopsin kinase
|
| Swissprots |
Q15835 Q53X14
|
| Accessions |
AAC97160 AAC97161 AAQ94192 AAT00534 EAX09222 Q15835 AK289912 BAF82601 BC140945 AAI40946 BM702747 BX647503 L77503 AAG50439 U63973 AAB05929 NM_002929 NP_002920
|
| Function |
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. {ECO:0000269|PubMed:15946941}.
|
| Subcellular Location |
Membrane {ECO:0000250|UniProtKB:P28327}; Lipid-anchor {ECO:0000250|UniProtKB:P28327}.
|
| Tissue Specificity |
Retinal-specific. Expressed in rods and cones cells. {ECO:0000269|PubMed:11717351}.
|
| Top Pathways |
Endocytosis, Chemokine signaling pathway, Phototransduction
|
![Western Blot: GRK1 Overexpression Lysate (Adult Normal) [NBL1-11342] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GRK1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9226_GRK1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11342-img0002.jpg)