| Gene Symbol | GRK1 |
|---|---|
| Entrez Gene | 6011 |
| Alt Symbol | GPRK1, RHOK, RK |
| Species | Human |
| Gene Type | protein-coding |
| Description | G protein-coupled receptor kinase 1 |
| Other Description | rhodopsin kinase |
| Swissprots | Q15835 Q53X14 |
| Accessions | AAC97160 AAC97161 AAQ94192 AAT00534 EAX09222 Q15835 AK289912 BAF82601 BC140945 AAI40946 BM702747 BX647503 L77503 AAG50439 U63973 AAB05929 NM_002929 NP_002920 |
| Function | Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. {ECO:0000269|PubMed:15946941}. |
| Subcellular Location | Membrane {ECO:0000250|UniProtKB:P28327}; Lipid-anchor {ECO:0000250|UniProtKB:P28327}. |
| Tissue Specificity | Retinal-specific. Expressed in rods and cones cells. {ECO:0000269|PubMed:11717351}. |
| Top Pathways | Endocytosis, Chemokine signaling pathway, Phototransduction |