Gene Symbol | KDM5D |
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Entrez Gene | 8284 |
Alt Symbol | HY, HYA, JARID1D, SMCY |
Species | Human |
Gene Type | protein-coding |
Description | lysine (K)-specific demethylase 5D |
Other Description | H-Y|Jumonji, AT rich interactive domain 1D (RBP2-like)|SMC homolog, Y chromosome|Smcy homolog, Y-linked|histocompatibility Y antigen|histone demethylase JARID1D|jumonji/ARID domain-containing protein 1D|lysine-specific demethylase 5D|protein SmcY|selected mouse cDNA on Y, human homolog of |
Swissprots | A6H8V7 Q9BY66 Q9HCU1 Q92809 B7ZLX1 A2RU19 Q92509 |
Accessions | AAG00951 AAK27839 EAW54663 EAW54664 Q9BY66 AA864889 AK095923 AK127269 BAG54468 AK304027 BAG64942 BC011053 BC132721 AAI32722 BC144101 BC144102 AAI44103 BC146767 AAI46768 BM052719 BM455812 BX648643 D87072 BAA13241 DA940867 U52191 AAC50806 U52365 AAC51135 XM_005262560 XP_005262617 XM_005262561 XP_005262618 XM_005262562 XP_005262619 XM_011531468 XP_011529770 XR_244571 XR_430568 XR_938609 XR_938610 NM_001146705 NP_001140177 NM_001146706 NP_001140178 NM_004653 NP_004644 |
Function | Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. {ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320162, ECO:0000269|PubMed:17351630}. |
Subcellular Location | Nucleus {ECO:0000305}. |
SmcY CRISPR/Cas9 KO Plasmid (h) - sc-403217 from Santa Cruz Biotechnology
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SmcY HDR Plasmid (h) - sc-403217-HDR from Santa Cruz Biotechnology
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SmcY Double Nickase Plasmid (h) - sc-403217-NIC from Santa Cruz Biotechnology
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SmcY Double Nickase Plasmid (h2) - sc-403217-NIC-2 from Santa Cruz Biotechnology
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SmcY CRISPR Activation Plasmid (h) - sc-403217-ACT from Santa Cruz Biotechnology
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SmcY CRISPR Activation Plasmid (h2) - sc-403217-ACT-2 from Santa Cruz Biotechnology
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SmcY Lentiviral Activation Particles (h) - sc-403217-LAC from Santa Cruz Biotechnology
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SmcY Lentiviral Activation Particles (h2) - sc-403217-LAC-2 from Santa Cruz Biotechnology
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SmcY siRNA (h) - sc-91559 from Santa Cruz Biotechnology
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SmcY shRNA Plasmid (h) - sc-91559-SH from Santa Cruz Biotechnology
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SmcY shRNA (h) Lentiviral Particles - sc-91559-V from Santa Cruz Biotechnology
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Jarid1D RNAi - H00008284-R01 from Novus Biologicals
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MISSION® esiRNA - EHU068131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11037 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11037 from Sigma-Aldrich
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KDM5D siRNA (Human) - CRH5421 from Cohesion Biosciences
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SmcY HDR Plasmid (h2) - sc-403217-HDR-2 from Santa Cruz Biotechnology
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SmcY CRISPR/Cas9 KO Plasmid (h2) - sc-403217-KO-2 from Santa Cruz Biotechnology
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Human KDM5D siRNA - orb265923 from Biorbyt
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KDM5D shRNA Plasmid (Human) - CHH5421 from Cohesion Biosciences
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KDM5D miRNA 3'UTR clone - MiUTR3H-03061 from Creative biogene
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KDM5D miRNA 3'UTR clone - MiUTR3H-03062 from Creative biogene
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KDM5D miRNA 3'UTR clone - MiUTR3H-03063 from Creative biogene
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