| Gene Symbol |
JPH4
|
| Entrez Gene |
84502
|
| Alt Symbol |
JP4, JPHL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
junctophilin 4
|
| Other Description |
JP-4|junctophilin like 1|junctophilin-4|junctophilin-like 1 protein
|
| Swissprots |
Q8ND44 D3DS53 Q96JJ6 Q96DQ0
|
| Accessions |
EAW66135 EAW66139 Q96JJ6 AB058734 BAB47460 AK055345 BAB70905 AK091572 AK290511 BAF83200 AK304514 BAH14203 AL834411 CAD39073 AY344068 AAS47836 BC055429 AAH55429 BC109228 DA108605 NM_001146028 NP_001139500 NM_032452 NP_115828
|
| Function |
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). {ECO:0000250}.
|