Gene Symbol | JPH4 |
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Entrez Gene | 84502 |
Alt Symbol | JP4, JPHL1 |
Species | Human |
Gene Type | protein-coding |
Description | junctophilin 4 |
Other Description | JP-4|junctophilin like 1|junctophilin-4|junctophilin-like 1 protein |
Swissprots | Q8ND44 D3DS53 Q96JJ6 Q96DQ0 |
Accessions | EAW66135 EAW66139 Q96JJ6 AB058734 BAB47460 AK055345 BAB70905 AK091572 AK290511 BAF83200 AK304514 BAH14203 AL834411 CAD39073 AY344068 AAS47836 BC055429 AAH55429 BC109228 DA108605 NM_001146028 NP_001139500 NM_032452 NP_115828 |
Function | Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). {ECO:0000250}. |
Junctophilin-4 CRISPR/Cas9 KO Plasmid (h) - sc-410198 from Santa Cruz Biotechnology
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Junctophilin-4 HDR Plasmid (h) - sc-410198-HDR from Santa Cruz Biotechnology
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Junctophilin-4 Double Nickase Plasmid (h) - sc-410198-NIC from Santa Cruz Biotechnology
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Junctophilin-4 Double Nickase Plasmid (h2) - sc-410198-NIC-2 from Santa Cruz Biotechnology
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Junctophilin-4 CRISPR Activation Plasmid (h) - sc-410198-ACT from Santa Cruz Biotechnology
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Junctophilin-4 CRISPR Activation Plasmid (h2) - sc-410198-ACT-2 from Santa Cruz Biotechnology
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Junctophilin-4 Lentiviral Activation Particles (h) - sc-410198-LAC from Santa Cruz Biotechnology
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Junctophilin-4 Lentiviral Activation Particles (h2) - sc-410198-LAC-2 from Santa Cruz Biotechnology
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Junctophilin-4 siRNA (h) - sc-92281 from Santa Cruz Biotechnology
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Junctophilin-4 shRNA Plasmid (h) - sc-92281-SH from Santa Cruz Biotechnology
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Junctophilin-4 shRNA (h) Lentiviral Particles - sc-92281-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10879 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10879 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09982 from Sigma-Aldrich
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JPH4 siRNA (Human) - CRJ3496 from Cohesion Biosciences
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JPH4, siRNA - MBS8237299 from MyBioSource
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shRNA set against Human JPH4 (NM_032452.2) - SHH322203 from Creative biogene
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Human JPH4 siRNA - orb273997 from Biorbyt
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JPH4 shRNA Plasmid (Human) - CHJ3496 from Cohesion Biosciences
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JPH4 miRNA 3'UTR clone - MiUTR3H-15193 from Creative biogene
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JPH4 miRNA 3'UTR clone - MiUTR3H-15194 from Creative biogene
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