| Gene Symbol |
INTU
|
| Entrez Gene |
27152
|
| Alt Symbol |
INT, PDZD6, PDZK6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inturned planar cell polarity protein
|
| Other Description |
PDZ domain containing 6|PDZ domain-containing protein 6|homolog of inturned|inturned planar cell polarity effector homolog|protein inturned
|
| Swissprots |
Q4W5I8 D6RBT4 Q86V55 A1L4N5 Q9ULD6 D6RAE6
|
| Accessions |
AAY41002 CAK32347 EAX05201 EAX05202 Q9ULD6 AB033110 BAA86598 AK123320 BAG53888 AK291481 BAF84170 BC051698 AAH51698 BC130611 AAI30612 BC144182 DB195553 DB302901 HQ234310 HQ234311 HQ258681 ADR83432 XM_011531844 XP_011530146 XM_011531845 XP_011530147 XM_011531846 XP_011530148 XM_011531847 XP_011530149 XM_011531848 XP_011530150 XM_011531849 XP_011530151 XM_011531850 XP_011530152 XM_011531851 XP_011530153 XR_938720 NM_015693 NP_056508
|
| Function |
Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell surface {ECO:0000250}. Note=Enriched at the apical surface in ciliated cells. {ECO:0000250}.
|
![Western Blot: INTU Overexpression Lysate (Adult Normal) [NBP2-07130] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for INTU.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1631_INTU%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07130-img0001.jpg)