Gene Symbol | APOA5 |
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Entrez Gene | 116519 |
Alt Symbol | APOAV, RAP3 |
Species | Human |
Gene Type | protein-coding |
Description | apolipoprotein A-V |
Other Description | apo-AV|apolipoprotein A5|regeneration-associated protein 3 |
Swissprots | Q9UBJ3 Q6UWK9 Q6Q788 B0YIV9 Q3MIK6 |
Accessions | AAQ91808 AAS68229 ACA05937 ACA05938 AIY32613 CAC24995 CAD88066 EAW67269 EAW67270 Q6Q788 AF202889 AAF25661 AF202890 AAF25662 AK292739 BAF85428 AK308047 AK315229 BAG37658 AY358749 AAQ89109 BC101787 AAI01788 BC101789 AAI01790 DA641693 DB184692 NM_001166598 NP_001160070 NM_052968 NP_443200 |
Function | Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. {ECO:0000250, ECO:0000269|PubMed:11588264, ECO:0000269|PubMed:12899628, ECO:0000269|PubMed:15528295}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:12810715}. |
Tissue Specificity | Liver and plasma. {ECO:0000269|PubMed:11577099, ECO:0000269|PubMed:11588264, ECO:0000269|PubMed:15528295}. |
Top Pathways | PPAR signaling pathway |
ApoA5 (2G1H11) Mouse mAb - 3335 from Cell Signaling Technology
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apoA-V (1F1E8) - sc-65992 from Santa Cruz Biotechnology
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apoA-V (A-12) - sc-393722 from Santa Cruz Biotechnology
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apoA-V (1G5G9) - sc-32809 from Santa Cruz Biotechnology
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apoA-V (2G1H11) - sc-65991 from Santa Cruz Biotechnology
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apoA-V (4H8H8E2) - sc-32810 from Santa Cruz Biotechnology
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apoA-V (C-12) - sc-33081 from Santa Cruz Biotechnology
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apoA-V (E-12) - sc-373950 from Santa Cruz Biotechnology
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apoA-V (H-300) - sc-66809 from Santa Cruz Biotechnology
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apoA-V (M-300) - sc-66810 from Santa Cruz Biotechnology
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apoA-V (N-13) - sc-33079 from Santa Cruz Biotechnology
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apoA-V (N-20) - sc-46063 from Santa Cruz Biotechnology
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Anti-Apolipoprotein A V antibody - ab77358 from Abcam
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Anti-Apolipoprotein A V antibody [2G1H11, 1F1E8] - ab115772 from Abcam
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Anti-Apolipoprotein A V antibody - Aminoterminal end - ab55977 from Abcam
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Anti-Apolipoprotein A V antibody - N-terminal - ab71265 from Abcam
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Anti-APOA5 / Apolipoprotein A V Antibody (N-Terminus) - LS-C46994 from LifeSpan Bioscience
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Anti-APOA5 / Apolipoprotein A V Antibody - LS-C69141 from LifeSpan Bioscience
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Anti-APOA5 / Apolipoprotein A V Antibody - LS-C69140 from LifeSpan Bioscience
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Anti-APOA5 / Apolipoprotein A V Antibody - LS-C41368 from LifeSpan Bioscience
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Anti-APOA5 / Apolipoprotein A V Antibody - LS-C69142 from LifeSpan Bioscience
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Anti-APOA5 / Apolipoprotein A V Antibody - LS-C69143 from LifeSpan Bioscience
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Anti-APOA5 / Apolipoprotein A V Antibody - LS-C69144 from LifeSpan Bioscience
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Anti-APOA5 / Apolipoprotein A V Antibody (clone 1G5G9) - LS-C47132 from LifeSpan Bioscience
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Anti-APOA5 / Apolipoprotein A V Antibody (clone 1G5G9) - LS-C47130 from LifeSpan Bioscience
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