Gene Symbol | APOA5 |
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Entrez Gene | 116519 |
Alt Symbol | APOAV, RAP3 |
Species | Human |
Gene Type | protein-coding |
Description | apolipoprotein A-V |
Other Description | apo-AV|apolipoprotein A5|regeneration-associated protein 3 |
Swissprots | Q9UBJ3 Q6UWK9 Q6Q788 B0YIV9 Q3MIK6 |
Accessions | AAQ91808 AAS68229 ACA05937 ACA05938 AIY32613 CAC24995 CAD88066 EAW67269 EAW67270 Q6Q788 AF202889 AAF25661 AF202890 AAF25662 AK292739 BAF85428 AK308047 AK315229 BAG37658 AY358749 AAQ89109 BC101787 AAI01788 BC101789 AAI01790 DA641693 DB184692 NM_001166598 NP_001160070 NM_052968 NP_443200 |
Function | Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. {ECO:0000250, ECO:0000269|PubMed:11588264, ECO:0000269|PubMed:12899628, ECO:0000269|PubMed:15528295}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:12810715}. |
Tissue Specificity | Liver and plasma. {ECO:0000269|PubMed:11577099, ECO:0000269|PubMed:11588264, ECO:0000269|PubMed:15528295}. |
Top Pathways | PPAR signaling pathway |
ApoA-V CRISPR/Cas9 KO Plasmid (h) - sc-402213 from Santa Cruz Biotechnology
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ApoA-V HDR Plasmid (h) - sc-402213-HDR from Santa Cruz Biotechnology
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ApoA-V Double Nickase Plasmid (h) - sc-402213-NIC from Santa Cruz Biotechnology
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ApoA-V Double Nickase Plasmid (h2) - sc-402213-NIC-2 from Santa Cruz Biotechnology
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ApoA-V CRISPR Activation Plasmid (h) - sc-402213-ACT from Santa Cruz Biotechnology
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ApoA-V CRISPR Activation Plasmid (h2) - sc-402213-ACT-2 from Santa Cruz Biotechnology
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ApoA-V Lentiviral Activation Particles (h) - sc-402213-LAC from Santa Cruz Biotechnology
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ApoA-V Lentiviral Activation Particles (h2) - sc-402213-LAC-2 from Santa Cruz Biotechnology
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apoA-V siRNA (h) - sc-44527 from Santa Cruz Biotechnology
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apoA-V shRNA Plasmid (h) - sc-44527-SH from Santa Cruz Biotechnology
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apoA-V shRNA (h) Lentiviral Particles - sc-44527-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN3330 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3330 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06417 from Sigma-Aldrich
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APOA5 siRNA (Human) - CRJ4525 from Cohesion Biosciences
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APOA5 - MBS8225938 from MyBioSource
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shRNA set against Human APOA5 (NM_052968.4) - SHH238366 from Creative biogene
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Human APOA5 siRNA - orb275026 from Biorbyt
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APOA5 shRNA Plasmid (Human) - CHJ4525 from Cohesion Biosciences
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APOA5 miRNA 3'UTR clone - MiUTR3H-08400 from Creative biogene
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