| Gene Symbol |
APOA5
|
| Entrez Gene |
116519
|
| Alt Symbol |
APOAV, RAP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apolipoprotein A-V
|
| Other Description |
apo-AV|apolipoprotein A5|regeneration-associated protein 3
|
| Swissprots |
Q9UBJ3 Q6UWK9 Q6Q788 B0YIV9 Q3MIK6
|
| Accessions |
AAQ91808 AAS68229 ACA05937 ACA05938 AIY32613 CAC24995 CAD88066 EAW67269 EAW67270 Q6Q788 AF202889 AAF25661 AF202890 AAF25662 AK292739 BAF85428 AK308047 AK315229 BAG37658 AY358749 AAQ89109 BC101787 AAI01788 BC101789 AAI01790 DA641693 DB184692 NM_001166598 NP_001160070 NM_052968 NP_443200
|
| Function |
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. {ECO:0000250, ECO:0000269|PubMed:11588264, ECO:0000269|PubMed:12899628, ECO:0000269|PubMed:15528295}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:12810715}.
|
| Tissue Specificity |
Liver and plasma. {ECO:0000269|PubMed:11577099, ECO:0000269|PubMed:11588264, ECO:0000269|PubMed:15528295}.
|
| Top Pathways |
PPAR signaling pathway
|