DUOX1

Gene Symbol DUOX1
Entrez Gene 53905
Alt Symbol LNOX1, NOXEF1, THOX1
Species Human
Gene Type protein-coding
Description dual oxidase 1
Other Description NADPH thyroid oxidase 1|flavoprotein NADPH oxidase|large NOX 1|long NOX 1|nicotinamide adenine dinucleotide phosphate oxidase|thyroid oxidase 1
Swissprots Q14C94 Q9NZC1 Q6ZR09 Q9NRD9 A6NH28 Q6ZMB3
Accessions CCQ43907 EAW77295 EAW77296 EAW77297 Q9NRD9 AF213465 AAF71295 AF230495 AAF73921 AK075268 AK128591 AK172859 BAD18816 AK290372 BAF83061 AL137592 CAB70831 BC114628 AAI14629 BC114938 AAI14939 CB852814 XM_011521681 XP_011519983 XM_011521682 XP_011519984 NM_017434 NP_059130 NM_175940 NP_787954
Function Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283}.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}; Multi- pass membrane protein {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}. Note=Localizes to the apical membrane of epithelial cells.
Tissue Specificity Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283, ECO:0000269|PubMed:15210697}.

DUOX1 (H-9) - sc-393096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DUOX1 (H-9): sc-393096. Western blot analysis of DUOX1 expression in H69AR (A), HCT-116 (B), A549 (C) and Mv 1 Lu (D) whole cell lysates.

DUOX1 (C-15) - sc-48856 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DUOX1 (H-65) - sc-98898 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

DUOX1 (S-18) - sc-48858 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DUOX1 (S-18): sc-48858. Western blot analysis of DUOX1 expression in Mv 1 Lu (A), A549 (B) and H69AR (C) whole cell lysates.

DUOX1 (T-14) - sc-48859 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DUOX1 antibody - ab78919 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human thyroid gland labeling DUOX1 with ab78919 at 4-6μg/ml. The image shows staining of membranes in epithelial cells of the thyroid gland.Steamed antigen retrieval with Tris/EDTA buffer pH 9 was performed. Antibody was detected by HRP-staining.

Anti-DUOX1 antibody - ab178534 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-DUOX1 antibody (ab178534) at 0.1 µg/ml + Human Testis lysate at 35 µgdeveloped using the ECL technique

Anti-DUOX Antibody (aa1020-1032) - LS-C54740 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-DUOX Antibody (aa972-985) - LS-C205005 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
DUOX1 antibody (0.1 ug/ml) staining of Human Testis lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

DUOX1 Antibody - NB100-93521 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry-Paraffin: DUOX1 Antibody [NB100-93521] - (4ug/ml) staining of paraffin embedded Human Thyroid Gland. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.

DUOX1 Antibody - NBP2-16232 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DUOX1 Antibody [NBP2-16232] - Various whole cell extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with DUOX1 antibody [N1N3] diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.

DUOX1 Antibody - NBP1-81301 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: DUOX1 Antibody [NBP1-81301] - Staining of human liver shows no membranous positivity in hepatocytes as expected.

DUOX1 Antibody - H00053905-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

DUOX1 Polyclonal Antibody - bs-11431R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-DUOX1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11431R-A350 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-DUOX1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11431R-A488 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-DUOX1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11431R-A555 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-DUOX1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11431R-A647 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-DUOX1 Polyclonal Antibody, Cy3 Conjugated - bs-11431R-Cy3 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-DUOX1 Polyclonal Antibody, Cy5 Conjugated - bs-11431R-Cy5 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-DUOX1 Polyclonal Antibody, Cy5.5 Conjugated - bs-11431R-Cy5.5 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-DUOX1 Polyclonal Antibody, Cy7 Conjugated - bs-11431R-Cy7 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-DUOX1 Polyclonal Antibody, FITC Conjugated - bs-11431R-FITC from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-DUOX1 Polyclonal Antibody, PE Conjugated - bs-11431R-PE from Bioss

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-DUOX1 Polyclonal Antibody, Biotin Conjugated - bs-11431R-Biotin from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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