| Gene Symbol |
DUOX1
|
| Entrez Gene |
53905
|
| Alt Symbol |
LNOX1, NOXEF1, THOX1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dual oxidase 1
|
| Other Description |
NADPH thyroid oxidase 1|flavoprotein NADPH oxidase|large NOX 1|long NOX 1|nicotinamide adenine dinucleotide phosphate oxidase|thyroid oxidase 1
|
| Swissprots |
Q14C94 Q9NZC1 Q6ZR09 Q9NRD9 A6NH28 Q6ZMB3
|
| Accessions |
CCQ43907 EAW77295 EAW77296 EAW77297 Q9NRD9 AF213465 AAF71295 AF230495 AAF73921 AK075268 AK128591 AK172859 BAD18816 AK290372 BAF83061 AL137592 CAB70831 BC114628 AAI14629 BC114938 AAI14939 CB852814 XM_011521681 XP_011519983 XM_011521682 XP_011519984 NM_017434 NP_059130 NM_175940 NP_787954
|
| Function |
Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283}.
|
| Subcellular Location |
Apical cell membrane {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}; Multi- pass membrane protein {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}. Note=Localizes to the apical membrane of epithelial cells.
|
| Tissue Specificity |
Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283, ECO:0000269|PubMed:15210697}.
|