DUOX1

Gene Symbol	DUOX1
Entrez Gene	53905
Alt Symbol	LNOX1, NOXEF1, THOX1
Species	Human
Gene Type	protein-coding
Description	dual oxidase 1
Other Description	NADPH thyroid oxidase 1|flavoprotein NADPH oxidase|large NOX 1|long NOX 1|nicotinamide adenine dinucleotide phosphate oxidase|thyroid oxidase 1
Swissprots	Q14C94 Q9NZC1 Q6ZR09 Q9NRD9 A6NH28 Q6ZMB3
Accessions	CCQ43907 EAW77295 EAW77296 EAW77297 Q9NRD9 AF213465 AAF71295 AF230495 AAF73921 AK075268 AK128591 AK172859 BAD18816 AK290372 BAF83061 AL137592 CAB70831 BC114628 AAI14629 BC114938 AAI14939 CB852814 XM_011521681 XP_011519983 XM_011521682 XP_011519984 NM_017434 NP_059130 NM_175940 NP_787954
Function	Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}; Multi- pass membrane protein {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}. Note=Localizes to the apical membrane of epithelial cells.
Tissue Specificity	Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283, ECO:0000269|PubMed:15210697}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DUOX1 protein fragment - ab162709 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human DUOX1 Protein - H00053905-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DUOX1 blocking peptide - GTX88773-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

DUOX1 Peptide - AC21-1544-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DUOX1 Peptide - AC21-2858-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Dual oxidase 1 - H00053905-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Dual oxidase 1 - H00053905-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Dual oxidase 1 Peptide - 45-501P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

DUOX1 fusion protein - ag18154 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

DUOX1 fusion protein - ag18110 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Dual oxidase 1 (transcript variant 2) - TP323832 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Dual oxidase 1 (transcript variant 1) - TP323975 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Dual oxidase 1, Peptide - MBS425600 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

DUOX1, Peptide - MBS428308 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

DUOX1 Recombinant Protein Antigen - NBP1-81301PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DUOX1 Peptide, Human - M34GP04589H from Creative Peptides Category Peptide Source Synthetic. Species Human

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