DUOX1
| Gene Symbol | DUOX1 |
|---|---|
| Entrez Gene | 53905 |
| Alt Symbol | LNOX1, NOXEF1, THOX1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dual oxidase 1 |
| Other Description | NADPH thyroid oxidase 1|flavoprotein NADPH oxidase|large NOX 1|long NOX 1|nicotinamide adenine dinucleotide phosphate oxidase|thyroid oxidase 1 |
| Swissprots | Q14C94 Q9NZC1 Q6ZR09 Q9NRD9 A6NH28 Q6ZMB3 |
| Accessions | CCQ43907 EAW77295 EAW77296 EAW77297 Q9NRD9 AF213465 AAF71295 AF230495 AAF73921 AK075268 AK128591 AK172859 BAD18816 AK290372 BAF83061 AL137592 CAB70831 BC114628 AAI14629 BC114938 AAI14939 CB852814 XM_011521681 XP_011519983 XM_011521682 XP_011519984 NM_017434 NP_059130 NM_175940 NP_787954 |
| Function | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283}. |
| Subcellular Location | Apical cell membrane {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}; Multi- pass membrane protein {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:15210697}. Note=Localizes to the apical membrane of epithelial cells. |
| Tissue Specificity | Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. {ECO:0000269|PubMed:10806195, ECO:0000269|PubMed:11514595, ECO:0000269|PubMed:12824283, ECO:0000269|PubMed:15210697}. |
DUOX1 CRISPR/Cas9 KO Plasmid (h) - sc-402745 from Santa Cruz Biotechnology
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DUOX1 HDR Plasmid (h) - sc-402745-HDR from Santa Cruz Biotechnology
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DUOX1 Double Nickase Plasmid (h) - sc-402745-NIC from Santa Cruz Biotechnology
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DUOX1 Double Nickase Plasmid (h2) - sc-402745-NIC-2 from Santa Cruz Biotechnology
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DUOX1 CRISPR Activation Plasmid (h) - sc-402745-ACT from Santa Cruz Biotechnology
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DUOX1 CRISPR Activation Plasmid (h2) - sc-402745-ACT-2 from Santa Cruz Biotechnology
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DUOX1 Lentiviral Activation Particles (h) - sc-402745-LAC from Santa Cruz Biotechnology
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DUOX1 Lentiviral Activation Particles (h2) - sc-402745-LAC-2 from Santa Cruz Biotechnology
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DUOX1 siRNA (h) - sc-60550 from Santa Cruz Biotechnology
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DUOX1 shRNA Plasmid (h) - sc-60550-SH from Santa Cruz Biotechnology
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DUOX1 shRNA (h) Lentiviral Particles - sc-60550-V from Santa Cruz Biotechnology
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DUOX1 RNAi - H00053905-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN7533 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7533 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05902 from Sigma-Aldrich
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DUOX1 siRNA (Human) - CRH9996 from Cohesion Biosciences
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DUOX1 RNAi - H00053905-R01 from Novus Biologicals
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DUOX1 - MBS8214050 from MyBioSource
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shRNA set against Human DUOX1 (NM_175940.1) - SHH281557 from Creative biogene
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shRNA set against Human DUOX1(NM_017434.3) - SHH018029 from Creative biogene
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shRNA set against Human DUOX1(NM_175940.1) - SHH018047 from Creative biogene
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DUOX1 CRISPR/Cas9 KO Plasmid (h2) - sc-402745-KO-2 from Santa Cruz Biotechnology
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DUOX1 HDR Plasmid (h2) - sc-402745-HDR-2 from Santa Cruz Biotechnology
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Human DUOX1 siRNA - orb270498 from Biorbyt
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DUOX1 shRNA Plasmid (Human) - CHH9996 from Cohesion Biosciences
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