| Gene Symbol |
PIP5K1B
|
| Entrez Gene |
8395
|
| Alt Symbol |
MSS4, STM7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
|
| Other Description |
PIP5K1-beta|PIP5KIbeta|phosphatidylinositol 4-phosphate 5-kinase type I beta|phosphatidylinositol 4-phosphate 5-kinase type-1 beta|phosphatidylinositol-4-phosphate 5-kinase type-1 beta|protein STM-7|ptdIns(4)P-5-kinase 1 beta|type I phosphatidylinositol 4-phosphate 5-kinase beta|type I phosphatidylinositol-4-phosphate 5-kinase beta
|
| Swissprots |
P78519 Q8NHQ5 Q5T5K8 Q92749 O14986 Q7KYT5 Q5T5K6 P78518 B4DIG7 Q5T5K9 Q5VZ00 A8K9L9
|
| Accessions |
AAC51327 EAW62465 EAW62466 EAW62467 O14986 AK292734 BAF85423 AK295587 BAG58479 BC030587 AAH30587 CB988216 CK299479 DQ890874 ABM81800 DQ894030 ABM84956 U78579 AAC50914 U78580 AAC50915 U78581 AAC50916 XM_005252261 XP_005252318 XM_005252262 XP_005252319 XM_006717300 XP_006717363 XM_006717301 XP_006717364 XM_011519082 XP_011517384 XM_011519083 XP_011517385 XM_011519084 XP_011517386 XM_011519085 XP_011517387 NM_001031687 NM_001278253 NP_001265182 NM_003558 NP_003549
|
| Function |
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endomembrane system {ECO:0000250}. Note=Associated with membranes. {ECO:0000250}.
|
| Tissue Specificity |
Detected in heart, pancreas, brain, kidney, skeletal muscle and lung. {ECO:0000269|PubMed:8955136}.
|
| Top Pathways |
Fc gamma R-mediated phagocytosis, Endocytosis, Choline metabolism in cancer, Inositol phosphate metabolism, Regulation of actin cytoskeleton
|