Gene Symbol | PIP5K1B |
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Entrez Gene | 8395 |
Alt Symbol | MSS4, STM7 |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidylinositol-4-phosphate 5-kinase, type I, beta |
Other Description | PIP5K1-beta|PIP5KIbeta|phosphatidylinositol 4-phosphate 5-kinase type I beta|phosphatidylinositol 4-phosphate 5-kinase type-1 beta|phosphatidylinositol-4-phosphate 5-kinase type-1 beta|protein STM-7|ptdIns(4)P-5-kinase 1 beta|type I phosphatidylinositol 4-phosphate 5-kinase beta|type I phosphatidylinositol-4-phosphate 5-kinase beta |
Swissprots | P78519 Q8NHQ5 Q5T5K8 Q92749 O14986 Q7KYT5 Q5T5K6 P78518 B4DIG7 Q5T5K9 Q5VZ00 A8K9L9 |
Accessions | AAC51327 EAW62465 EAW62466 EAW62467 O14986 AK292734 BAF85423 AK295587 BAG58479 BC030587 AAH30587 CB988216 CK299479 DQ890874 ABM81800 DQ894030 ABM84956 U78579 AAC50914 U78580 AAC50915 U78581 AAC50916 XM_005252261 XP_005252318 XM_005252262 XP_005252319 XM_006717300 XP_006717363 XM_006717301 XP_006717364 XM_011519082 XP_011517384 XM_011519083 XP_011517385 XM_011519084 XP_011517386 XM_011519085 XP_011517387 NM_001031687 NM_001278253 NP_001265182 NM_003558 NP_003549 |
Function | Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity). {ECO:0000250}. |
Subcellular Location | Endomembrane system {ECO:0000250}. Note=Associated with membranes. {ECO:0000250}. |
Tissue Specificity | Detected in heart, pancreas, brain, kidney, skeletal muscle and lung. {ECO:0000269|PubMed:8955136}. |
Top Pathways | Fc gamma R-mediated phagocytosis, Endocytosis, Choline metabolism in cancer, Inositol phosphate metabolism, Regulation of actin cytoskeleton |
PIPK I β siRNA (h) - sc-39135 from Santa Cruz Biotechnology
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PIPK I β shRNA Plasmid (h) - sc-39135-SH from Santa Cruz Biotechnology
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PIPK I β shRNA (h) Lentiviral Particles - sc-39135-V from Santa Cruz Biotechnology
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MSS4 RNAi - H00008395-R02 from Novus Biologicals
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MISSION® esiRNA - EHU076071 from Sigma-Aldrich
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MISSION® siRNA - SIHK1706 from Sigma-Aldrich
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MISSION® siRNA - SIHK1703 from Sigma-Aldrich
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MISSION® siRNA - SIHK1704 from Sigma-Aldrich
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MISSION® siRNA - SIHK1707 from Sigma-Aldrich
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MISSION® siRNA - SIHK1705 from Sigma-Aldrich
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MISSION® siRNA - SIHK1702 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16827 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16827 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06234 from Sigma-Aldrich
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PIP5K1B siRNA (Human) - CRH5501 from Cohesion Biosciences
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shRNA set against Human PIP5K1B (NM_003558.2) - SHH376040 from Creative biogene
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shRNA set against Human PIP5K1B(NM_003558.2) - SHR115638 from Creative biogene
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Human PIP5K1B siRNA - orb266003 from Biorbyt
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PIP5K1B shRNA Plasmid (Human) - CHH5501 from Cohesion Biosciences
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PIP5K1B miRNA 3'UTR clone - MiUTR1H-07923 from Creative biogene
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