| Gene Symbol | PPFIA1 |
|---|---|
| Entrez Gene | 8500 |
| Alt Symbol | LIP.1, LIP1, LIPRIN |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 |
| Other Description | LAR-interacting protein 1|LIP-1|Liprin-alpha1|PTPRF-interacting protein alpha-1|liprin-alpha-1|protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1 |
| Swissprots | Q8N4I2 Q14567 A6NLE3 Q13136 Q13135 |
| Accessions | EAW74763 EAW74764 EAW74765 Q13136 AB209314 BAD92551 AK123331 BAG53890 AK124621 BAG54059 AW163189 BC034046 AAH34046 BF352121 BX648037 CK902590 D49354 BAA08353 DQ892401 ABM83327 U22815 AAC50172 U22816 AAC50173 XM_006718716 XP_006718779 XM_011545306 XP_011543608 XM_011545307 XP_011543609 XM_011545308 XP_011543610 XM_011545309 XP_011543611 XM_011545310 XP_011543612 XM_011545311 XP_011543613 XM_011545312 XP_011543614 XM_011545313 XP_011543615 XM_011545314 XP_011543616 XM_011545315 XP_011543617 XM_011545316 XP_011543618 XM_011545317 XP_011543619 XM_011545318 XP_011543620 XM_011545319 XP_011543621 NM_003626 NP_003617 NM_177423 NP_803172 NR_045286 |
| Function | May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:7796809}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:7796809}. Note=Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:7796809, ECO:0000269|PubMed:9624153}. |
Liprin α1 CRISPR/Cas9 KO Plasmid (h) - sc-405468 from Santa Cruz Biotechnology
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Liprin α1 HDR Plasmid (h) - sc-405468-HDR from Santa Cruz Biotechnology
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Liprin α1 Double Nickase Plasmid (h) - sc-405468-NIC from Santa Cruz Biotechnology
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Liprin α1 Double Nickase Plasmid (h2) - sc-405468-NIC-2 from Santa Cruz Biotechnology
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Liprin α1 CRISPR Activation Plasmid (h) - sc-405468-ACT from Santa Cruz Biotechnology
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Liprin α1 CRISPR Activation Plasmid (h2) - sc-405468-ACT-2 from Santa Cruz Biotechnology
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Liprin α1 Lentiviral Activation Particles (h) - sc-405468-LAC from Santa Cruz Biotechnology
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Liprin α1 Lentiviral Activation Particles (h2) - sc-405468-LAC-2 from Santa Cruz Biotechnology
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Liprin α1 siRNA (h) - sc-72330 from Santa Cruz Biotechnology
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Liprin α1 shRNA Plasmid (h) - sc-72330-SH from Santa Cruz Biotechnology
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Liprin α1 shRNA (h) Lentiviral Particles - sc-72330-V from Santa Cruz Biotechnology
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MISSION® Human Phosphatase - SIHP0464 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1011 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1010 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0463 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0465 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17212 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17212 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09364 from Sigma-Aldrich
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PPFIA1 siRNA (Human) - CRH5574 from Cohesion Biosciences
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shRNA set against Human PPFIA1 (NM_177423.2) - SHH380473 from Creative biogene
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PPFIA1 shRNA Plasmid (Human) - CHH5574 from Cohesion Biosciences
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PPFIA1 miRNA 3'UTR clone - MiUTR3H-11630 from Creative biogene
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PPFIA1 miRNA 3'UTR clone - MiUTR3H-11631 from Creative biogene
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