| Gene Symbol |
CASP12
|
| Entrez Gene |
100506742
|
| Alt Symbol |
CASP-12, CASP12P1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
caspase 12 (gene/pseudogene)
|
| Other Description |
caspase 12 pseudogene 1|inactive caspase-12
|
| Swissprots |
Q6UXS9 D6RBN7
|
| Accessions |
Q6UXS9 AF464191 AF464192 AF464193 AF464194 AF464195 AF486844 AF486845 AF486846 AF486847 AY358222 AAQ88589 BG183061 NM_001191016 NP_001177945 NR_034061 NR_034063 NR_034064 NR_034065 NR_034066 NR_034067 NR_034068 NR_034070 NR_034071 NR_000035
|
| Function |
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. {ECO:0000269|PubMed:12054529, ECO:0000269|PubMed:15129283}.
|
| Tissue Specificity |
Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. {ECO:0000269|PubMed:12054529}.
|
| Top Pathways |
Apoptosis, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Prion diseases, Protein processing in endoplasmic reticulum
|