Gene Symbol | CASP12 |
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Entrez Gene | 100506742 |
Alt Symbol | CASP-12, CASP12P1 |
Species | Human |
Gene Type | protein-coding |
Description | caspase 12 (gene/pseudogene) |
Other Description | caspase 12 pseudogene 1|inactive caspase-12 |
Swissprots | Q6UXS9 D6RBN7 |
Accessions | Q6UXS9 AF464191 AF464192 AF464193 AF464194 AF464195 AF486844 AF486845 AF486846 AF486847 AY358222 AAQ88589 BG183061 NM_001191016 NP_001177945 NR_034061 NR_034063 NR_034064 NR_034065 NR_034066 NR_034067 NR_034068 NR_034070 NR_034071 NR_000035 |
Function | Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. {ECO:0000269|PubMed:12054529, ECO:0000269|PubMed:15129283}. |
Tissue Specificity | Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. {ECO:0000269|PubMed:12054529}. |
Top Pathways | Apoptosis, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Prion diseases, Protein processing in endoplasmic reticulum |
caspase-12 CRISPR/Cas9 KO Plasmid (h) - sc-418877 from Santa Cruz Biotechnology
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caspase-12 HDR Plasmid (h) - sc-418877-HDR from Santa Cruz Biotechnology
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caspase-12 Double Nickase Plasmid (h) - sc-418877-NIC from Santa Cruz Biotechnology
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caspase-12 Double Nickase Plasmid (h2) - sc-418877-NIC-2 from Santa Cruz Biotechnology
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caspase-12 CRISPR Activation Plasmid (h) - sc-418877-ACT from Santa Cruz Biotechnology
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caspase-12 CRISPR Activation Plasmid (h2) - sc-418877-ACT-2 from Santa Cruz Biotechnology
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caspase-12 Lentiviral Activation Particles (h) - sc-418877-LAC from Santa Cruz Biotechnology
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caspase-12 Lentiviral Activation Particles (h2) - sc-418877-LAC-2 from Santa Cruz Biotechnology
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CASP12 siRNA (Human) - CRJ8925 from Cohesion Biosciences
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CASP12 - MBS8211681 from MyBioSource
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shRNA set against Human CASP12(NM_001191016.1) - SHG142241 from Creative biogene
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Human CASP12 siRNA - orb279426 from Biorbyt
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CASP12 shRNA Plasmid (Human) - CHJ8925 from Cohesion Biosciences
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CASP12 miRNA 3'UTR clone - MiUTR1H-01681 from Creative biogene
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