| Gene Symbol |
FBXL5
|
| Entrez Gene |
26234
|
| Alt Symbol |
FBL4, FBL5, FLR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
F-box and leucine-rich repeat protein 5
|
| Other Description |
F-box protein FBL4/FBL5|F-box protein FBL5|F-box/LRR-repeat protein 5|p45SKP2-like protein
|
| Swissprots |
Q9P0X5 Q9UKC8 Q9UKA1 B4DIB5 Q4W5A8 Q9UJT7 Q9NXN2 Q9P0I0 A8MSK4 Q8NHP3
|
| Accessions |
AAY40929 EAW92736 EAW92737 EAW92738 EAW92739 Q9UKA1 AF052097 AF142481 AAF66616 AF157323 AAF67489 AF174591 AAF04512 AF176700 AAF03700 AF199420 AAF09249 AI858616 AK000153 BAA90978 AK295510 BAG58427 AK310860 AL832808 AM392665 CAL37543 AM393475 CAL38352 BC012320 BC030656 AAH30656 BF432189 BI464829 BQ008436 BX537957 CAD97924 DB080171 DQ892452 ABM83378 DQ895664 ABM86590 XM_006713959 XP_006714022 XM_011513831 XP_011512133 XM_011513832 XP_011512134 XM_011513833 XP_011512135 NM_001193534 NP_001180463 NM_001193535 NP_001180464 NM_012161 NP_036293 NR_036464
|
| Function |
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued. {ECO:0000269|PubMed:17532294, ECO:0000269|PubMed:19762596, ECO:0000269|PubMed:19762597}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:17532294}.
|