FBXL5

Gene Symbol FBXL5
Entrez Gene 26234
Alt Symbol FBL4, FBL5, FLR1
Species Human
Gene Type protein-coding
Description F-box and leucine-rich repeat protein 5
Other Description F-box protein FBL4/FBL5|F-box protein FBL5|F-box/LRR-repeat protein 5|p45SKP2-like protein
Swissprots Q9P0X5 Q9UKC8 Q9UKA1 B4DIB5 Q4W5A8 Q9UJT7 Q9NXN2 Q9P0I0 A8MSK4 Q8NHP3
Accessions AAY40929 EAW92736 EAW92737 EAW92738 EAW92739 Q9UKA1 AF052097 AF142481 AAF66616 AF157323 AAF67489 AF174591 AAF04512 AF176700 AAF03700 AF199420 AAF09249 AI858616 AK000153 BAA90978 AK295510 BAG58427 AK310860 AL832808 AM392665 CAL37543 AM393475 CAL38352 BC012320 BC030656 AAH30656 BF432189 BI464829 BQ008436 BX537957 CAD97924 DB080171 DQ892452 ABM83378 DQ895664 ABM86590 XM_006713959 XP_006714022 XM_011513831 XP_011512133 XM_011513832 XP_011512134 XM_011513833 XP_011512135 NM_001193534 NP_001180463 NM_001193535 NP_001180464 NM_012161 NP_036293 NR_036464
Function Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued. {ECO:0000269|PubMed:17532294, ECO:0000269|PubMed:19762596, ECO:0000269|PubMed:19762597}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000269|PubMed:17532294}.

FBL5 CRISPR/Cas9 KO Plasmid (h) - sc-417743 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL5 HDR Plasmid (h) - sc-417743-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL5 Double Nickase Plasmid (h) - sc-417743-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL5 Double Nickase Plasmid (h2) - sc-417743-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL5 CRISPR Activation Plasmid (h) - sc-417743-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL5 CRISPR Activation Plasmid (h2) - sc-417743-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL5 Lentiviral Activation Particles (h) - sc-417743-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL5 Lentiviral Activation Particles (h2) - sc-417743-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FBL5 siRNA (h) - sc-62302 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBL5 shRNA Plasmid (h) - sc-62302-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBL5 shRNA (h) Lentiviral Particles - sc-62302-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FBXL5 RNAi - H00026234-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU029531 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8528 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8528 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08705 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08705

FBXL5 siRNA (Human) - CRH8770 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBXL5 RNAi - H00026234-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

FBXL5 - MBS8208802 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FBXL5 (NM_012161.3) - SHH292977 from Creative biogene

Category siRNA
Species Reactivities Human

Human FBXL5 siRNA - orb269272 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FBXL5 shRNA Plasmid (Human) - CHH8770 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FBXL5 miRNA 3'UTR clone - MiUTR3H-07861 from Creative biogene

Species Reactivities Human
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