FBXL5

Gene Symbol FBXL5
Entrez Gene 26234
Alt Symbol FBL4, FBL5, FLR1
Species Human
Gene Type protein-coding
Description F-box and leucine-rich repeat protein 5
Other Description F-box protein FBL4/FBL5|F-box protein FBL5|F-box/LRR-repeat protein 5|p45SKP2-like protein
Swissprots Q9P0X5 Q9UKC8 Q9UKA1 B4DIB5 Q4W5A8 Q9UJT7 Q9NXN2 Q9P0I0 A8MSK4 Q8NHP3
Accessions AAY40929 EAW92736 EAW92737 EAW92738 EAW92739 Q9UKA1 AF052097 AF142481 AAF66616 AF157323 AAF67489 AF174591 AAF04512 AF176700 AAF03700 AF199420 AAF09249 AI858616 AK000153 BAA90978 AK295510 BAG58427 AK310860 AL832808 AM392665 CAL37543 AM393475 CAL38352 BC012320 BC030656 AAH30656 BF432189 BI464829 BQ008436 BX537957 CAD97924 DB080171 DQ892452 ABM83378 DQ895664 ABM86590 XM_006713959 XP_006714022 XM_011513831 XP_011512133 XM_011513832 XP_011512134 XM_011513833 XP_011512135 NM_001193534 NP_001180463 NM_001193535 NP_001180464 NM_012161 NP_036293 NR_036464
Function Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued. {ECO:0000269|PubMed:17532294, ECO:0000269|PubMed:19762596, ECO:0000269|PubMed:19762597}.
Subcellular Location Cytoplasm, perinuclear region {ECO:0000269|PubMed:17532294}.

FBL4 (H-300) - sc-367198 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FBL4 (H-300): sc-367198. Western blot analysis of FBL4 expression in non-transfected: sc-117752 (A) and human FBL4 transfected: sc-116462 (B) 293T whole cell lysates.

FBL5 (H-300) - sc-134984 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FBL5 (H-300): sc-134984. Western blot analysis of FBL5 expression in DU 145 (A), K-562 (B), RT-4 (C) and PC-3 (D) whole cell lysates.

FBL5 (G-11) - sc-390102 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FBL5 (G-11): sc-390102. Western blot analysis of FBL5 expression in HL-60 (A), AML-193 (B), RAW 264.7 (C), J774.A1 (D) and WEHI-3 (E) whole cell lysates.

FBL5 (N-17) - sc-54364 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-FBXL5 antibody - ab140175 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab140175 staining FBXL5 in Mouse 14.5dpc tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 1% BSA for 1 hour at room temperature; antigen retrieval was by heat mediation in Tris pH 9. Samples were incubated with primary antibody (1/100 in 1% BSA + 1%FBS in TBS) for 16 hours. An undiluted HRP-conjugated Goat anti-rabbit IgG polyclonal was used as the secondary antibody.See Abreview

Anti-FBXL5 antibody - ab102692 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-FBXL5 antibody (ab102692) at 1/100 dilution + HepG2 cell line lysates at 35 µg

Anti-FBXL5 antibody - ab68069 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-FBXL5 antibody (ab68069) at 1/500 dilutionLane 1 : FBXL5 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-FBXL5 / FBL5 Antibody (aa93-123, AP) - LS-C214151 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL5 / FBL5 Antibody (aa93-123, APC) - LS-C214152 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL5 / FBL5 Antibody (aa93-123, Biotin) - LS-C214153 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL5 / FBL5 Antibody (aa251-300) - LS-C31926 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
FBXL5 antibody LS-C31926 was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.

Anti-FBXL5 / FBL5 Antibody (aa93-123, Azide-free, HRP) - LS-C214154 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL5 / FBL5 Antibody (aa93-123, FITC) - LS-C214155 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL5 / FBL5 Antibody (aa557-606) - LS-C116225 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FBXL5 antibody LS-C116225 Western blot of THP-1 cell lysate.

Anti-FBXL5 / FBL5 Antibody (aa93-123, PE) - LS-C214156 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL5 / FBL5 Antibody - LS-C307493 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-FBXL5 / FBL5 Antibody (aa93-123) - LS-C329540 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBXL5 / FBL5 Antibody - LS-C334157 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HepG2 cell line, using FBXL5 antibody.

Anti-FBXL5 / FBL5 Antibody (aa86-115) - LS-C166075 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FBXL5 Antibody IHC of formalin-fixed and paraffin-embedded testis tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-FBXL5 / FBL5 Antibody (aa510-691) IHC-plus™ - LS-B10242 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-FBXL5 / FBL5 antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10242 concentration 10 ug/ml.

FBXL5 Antibody - NBP1-54918 from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FBXL5 Antibody [NBP1-54918] - HepG2 cell lysate, Antibody Titration: 5.0ug/ml

FBXL5 Antibody - NBP1-54917 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

FBXL5 Antibody - H00026234-B01P from Novus Biologicals

Prices $349.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: FBXL5 Antibody [H00026234-B01P] - analysis of FBXL5 expression in transfected 293T cell line by FBXL5 MaxPab polyclonal antibody. Lane 1: FBXL5 transfected lysate (76.01 KDa). Lane 2: Non-transfected lysate.

FBXL5 Antibody - H00026234-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: FBXL5 Antibody [H00026234-A01] - FBXL5 polyclonal antibody (A01), Lot # 051123JCS1 Western Blot analysis of FBXL5 expression in HepG2 ( Cat # L019V1 ).

Anti-FBXL5 antibody produced in rabbit - AV43104 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-FBXL5: <B>Cat. No. AV43104</B>: Immunohistochemistry of FBXL5 in Human Muscle tissue with FBXL5 antibody at 4-8 μg/mL.
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