| Gene Symbol |
LRRC8B
|
| Entrez Gene |
23507
|
| Alt Symbol |
TA-LRRP, TALRRP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing 8 family, member B
|
| Other Description |
T cell activation leucine repeat rich protein|T-cell activation leucine repeat-rich protein|leucine-rich repeat-containing protein 8B|volume-regulated anion channel subunit LRRC8B
|
| Swissprots |
Q6UY21 D3DT28 Q8N106 Q92627 Q6P9F7
|
| Accessions |
EAW73137 EAW73138 Q6P9F7 AF385436 AAM43837 AW022123 AY358112 AAQ88479 AY640232 AAU14245 BC030607 AAH30607 BC035081 BC037831 AAH37831 BC053565 BC060782 AAH60782 BI459217 D86984 BAA13220 XM_005270701 XP_005270758 XM_005270702 XP_005270759 XM_005270703 XP_005270760 XM_011541143 XP_011539445 XM_011541144 XP_011539446 XM_011541145 XP_011539447 XM_011541146 XP_011539448 XM_011541147 XP_011539449 XM_011541148 XP_011539450 NM_001134476 NP_001127948 NM_015350 NP_056165
|
| Function |
Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8B constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|