| Gene Symbol | Bad |
|---|---|
| Entrez Gene | 12015 |
| Alt Symbol | AI325008, Bbc2 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | BCL2-associated agonist of cell death |
| Other Description | bcl-2-binding component 6|bcl-xL/Bcl-2-associated death promoter|bcl2 antagonist of cell death|bcl2-associated agonist of cell death |
| Swissprots | Q61337 |
| Accessions | EDL33265 EDL33266 Q61337 AK029400 AK131666 BAE20753 AK151792 BAE30693 AK169002 BAE40801 BC006762 AAH06762 L37296 AAA64465 NM_001285453 NP_001272382 NM_007522 NP_031548 |
| Function | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. |
| Subcellular Location | Mitochondrion outer membrane. Cytoplasm {ECO:0000269|PubMed:21546903}. Note=Colocalizes with HIF3A isoform 2 in the cytoplasm (PubMed:21546903). Upon phosphorylation, locates to the cytoplasm. {ECO:0000269|PubMed:21546903}. |
| Top Pathways | Apoptosis, Hepatitis C, cGMP-PKG signaling pathway, PI3K-Akt signaling pathway, Viral carcinogenesis |