MYOC

Gene Symbol	MYOC
Entrez Gene	4653
Alt Symbol	GLC1A, GPOA, JOAG, JOAG1, TIGR, myocilin
Species	Human
Gene Type	protein-coding
Description	myocilin, trabecular meshwork inducible glucocorticoid response
Other Description	mutated trabecular meshwork-induced glucocorticoid response protein|myocilin|myocilin 55 kDa subunit
Swissprots	O00620 Q7Z6Q9 B2RD84 Q99972
Accessions	AAC14264 AAT09137 BAA24532 CAB09899 EAW90903 Q99972 AF001620 AAC51725 AK097310 BAC04997 AK300924 BAG62556 AK300943 BAG62572 AK301297 BAG62854 AK315443 BAG37831 BC029261 AAH29261 D88214 BAA23531 DQ892415 ABM83341 DQ895629 ABM86555 FJ227302 ACI42983 FJ237046 ACI62292 FJ237047 ACI62293 U85257 AAC52051 NM_000261 NP_000252
Function	Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-assoc
Subcellular Location	Myocilin, N-terminal fragment: Endoplasmic reticulum. Note=Remains retained in the endoplasmic reticulum.
Tissue Specificity	Expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart, bone marrow-derived mesenchymal stem cells and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma. The myocilin 35 kDa fragment is detected in aqueous humor and at the less extend in iris and ciliary body. {ECO:0000269|PubMed:15795224}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

myocilin (F-12) - sc-137233 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

myocilin (C-15) - sc-21245 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

myocilin (H-130) - sc-20976 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

myocilin (N-15) - sc-21243 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Myocilin antibody - ab41552 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Myocilin antibody - ab55477 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-Myocilin antibody - ab85842 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MYOC / Myocilin Antibody (aa275-291) - LS-C3209 from LifeSpan Bioscience Prices $265.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MYOC / Myocilin Antibody (aa224-471, Biotin) - LS-C298085 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MYOC / Myocilin Antibody (aa224-471, FITC) - LS-C305210 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MYOC / Myocilin Antibody (aa36-135, Azide-free) - LS-C327957 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-MYOC / Myocilin Antibody (aa101-150) - LS-C187234 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MYOC / Myocilin Antibody - LS-C192844 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MYOC / Myocilin Antibody (aa224-471) - LS-C295476 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MYOC / Myocilin Antibody - LS-C331563 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MYOC / Myocilin Antibody (clone 4F8) IHC-plus™ - LS-B4382 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 4F8

Anti-MYOC / Myocilin Antibody (aa69-85) IHC-plus™ - LS-B2262 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Myocilin Antibody [Unconjugated] - AF2537 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

Myocilin Antibody (4F8) - H00004653-M01 from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 4F8

Myocilin Antibody (297817) - MAB3446 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 297817

Myocilin Antibody - NBP1-89769 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Myocilin Antibody - H00004653-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Myocilin Antibody (2B4) - H00004653-M02 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2B4

Myocilin Antibody - H00004653-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Myocilin Antibody - NBP1-40064 from Novus Biologicals Prices $329.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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